The Emerging Roles of Long Noncoding RNAs as Hallmarks of Lung Cancer.
The Emerging Roles of Long Noncoding RNAs as Hallmarks of Lung Cancer.
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长非编码 RNA 作为肺癌标志的新作用
DOI：
10.3389/fonc.2021.761582
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发表时间：
2021
影响因子：
4.7
通讯作者：
Zhang R
中科院分区：
文献类型：
--
作者：
Jiang J;Lu Y;Zhang F;Huang J;Ren XL;Zhang R
非编码核糖核酸（ncRNA）与肺癌的发生、生长和进展密切相关。长链非编码RNA（longncRNA，lncRNA）作为ncRNA的三个亚类之一，在染色质修饰、转录和转录后加工中发挥重要作用。最近已经报道了各种lncRNA在癌症中功能失调或失调，并且具有促肿瘤或抗肿瘤潜力。重要的是，作为一类新的癌症生物标志物，研究已经证明了使用某些lncRNA子集作为有希望的诊断、治疗或预后策略来管理癌症的可行性。本文综述了与肺癌标志物相关的lncRNA，特别是近五年来发现的lncRNA。这些lncRNA在肿瘤样本中的表达水平进行了讨论，以及它们的作用机制，耐药性和作为肺癌诊断和预后标志物的潜力。
Noncoding ribonucleic acids (ncRNAs) are closely associated with tumor initiation, growth, and progress in lung cancer. Long ncRNAs (lncRNAs), as one of the three subclasses of ncRNAs, play important roles in chromatin modification, transcription, and post-transcriptional processing. Various lncRNAs have recently been reported to be dysfunctional or dysregulated in cancers and have pro- or anti-tumor potential. Importantly, as a new class of cancer biomarkers, studies have demonstrated the plausibility of using certain subsets of lncRNAs as promising diagnostic, therapeutic, or prognostic strategies to manage cancers. This review focuses on lncRNAs associated with hallmarks of lung cancer, especially those discovered in the last five years. The expression levels of these lncRNAs in tumor samples are discussed, alongside their mechanisms of action, drug resistance, and potential as diagnostic and prognostic markers for lung cancer.
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影响因子：
10.5
作者：
Cabili, Moran N.;Trapnell, Cole;Rinn, John L.
通讯作者：
Rinn, John L.
DOI：
10.1158/1078-0432.ccr-12-3946
发表时间：
2013-12-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Behrens C;Solis LM;Lin H;Yuan P;Tang X;Kadara H;Riquelme E;Galindo H;Moran CA;Kalhor N;Swisher SG;Simon GR;Stewart DJ;Lee JJ;Wistuba II
通讯作者：
Wistuba II
影响因子：
30.8
作者：
Bass, Adam J.;Watanabe, Hideo;Mermel, Craig H.;Yu, Soyoung;Perner, Sven;Verhaak, Roel G.;Kim, So Young;Wardwell, Leslie;Tamayo, Pablo;Gat-Viks, Irit;Ramos, Alex H.;Woo, Michele S.;Weir, Barbara A.;Getz, Gad;Beroukhim, Rameen;O'Kelly, Michael;Dutt, Amit;Rozenblatt-Rosen, Orit;Dziunycz, Piotr;Komisarof, Justin;Chirieac, Lucian R.;LaFargue, Christopher J.;Scheble, Veit;Wilbertz, Theresia;Ma, Changqing;Rao, Shilpa;Nakagawa, Hiroshi;Stairs, Douglas B.;Lin, Lin;Giordano, Thomas J.;Wagner, Patrick;Minna, John D.;Gazdar, Adi F.;Zhu, Chang Qi;Brose, Marcia S.;Cecconello, Ivan;Ribeiro, Ulysses, Jr.;Marie, Suely K.;Dahl, Olav;Shivdasani, Ramesh A.;Tsao, Ming-Sound;Rubin, Mark A.;Wong, Kwok K.;Regev, Aviv;Hahn, William C.;Beer, David G.;Rustgi, Anil K.;Meyerson, Matthew
通讯作者：
Meyerson, Matthew
TFAP2C 激活的 MALAT1 调节多西他赛耐药肺腺癌细胞的化疗耐药性
DOI：
10.1016/j.omtn.2019.01.005
发表时间：
2019-03-01
期刊：
MOLECULAR THERAPY NUCLEIC ACIDS
影响因子：
--
作者：
Chen, Jing;Liu, Xiaobei;Chen, Longbang
通讯作者：
Chen, Longbang
影响因子：
2.7
作者：
Gong, Wenjing;Su, Yi;Wang, Xiumei
通讯作者：
Wang, Xiumei