Blocked-micropores, surface functionalized, bio-compatible and silica-coated iron oxide nanocomposites as advanced MRI contrast agent
Blocked-micropores, surface functionalized, bio-compatible and silica-coated iron oxide nanocomposites as advanced MRI contrast agent
复制标题
堵塞微孔、表面功能化、生物相容性和二氧化硅涂层氧化铁纳米复合材料作为先进 MRI 造影剂
DOI：
10.1007/s11051-013-1664-8
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发表时间：
2013
影响因子：
2.5
通讯作者：
H. Wende
中科院分区：
文献类型：
--
作者：
M. Darbandi;S. Laurent;M. Busch;Z. - A. Li;Y. Yuan;M. Krüger;M. Farle;M. Winterer;L. Vander Elst;R. N. Muller;H. Wende
近年来，生物相容性磁性纳米粒子在标记、成像、传感和分离等生物医学领域的应用越来越广泛。在这篇文章中，二氧化硅包覆的氧化铁纳米粒子（IONP）的表面改性方案的设计和开发的系统研究，通过一锅，在室温下原位方法。在油包水型微乳液中制备了二氧化硅包覆的IONP，随后通过向微乳液体系中加入有机硅烷试剂对IONP进行表面改性。通过透射电子显微镜（TEM）和N2吸附-脱附测量研究了合成纳米颗粒的结构和形态。电子衍射和高分辨率透射电子显微镜（TEM）的纳米粒子的图像显示了高度结晶的IONP结构的性质。氮吸附分别表明二氧化硅涂覆的和胺官能化的二氧化硅涂覆的IONP的微孔和堵塞的微孔结构，这可以证明官能化的最终产物的细胞毒性较小。此外，最终产物的胶体稳定性和表面层上的改性官能团的存在已被证明由zeta电位测量。由于内部IONP核和亲水性二氧化硅壳的益处，所合成的纳米复合材料被开发作为MRI对比增强剂。弛豫实验结果表明，表面功能化的IONP也具有信号增强特性。这些表面功能化的纳米复合材料不仅是用于MRI的高效造影剂的潜在候选者，而且还可以用作超灵敏的生物磁性标记物，因为它们是纳米尺寸的，具有磁性，堵塞微孔并且在生物环境中分散良好。
Biocompatible magnetic nanoparticles have been found promising in several biomedical applications for tagging, imaging, sensing and separation in recent years. In this article, a systematic study of the design and development of surface-modification schemes for silica-coated iron oxide nanoparticles (IONP) via a one-pot, in situ method at room temperature is presented. Silica-coated IONP were prepared in a water-in-oil microemulsion, and subsequently the surface was modified via addition of organosilane reagents to the microemulsion system. The structure and the morphology of the as synthesized nanoparticles have been investigated by means of transmission electron microscopy (TEM) and measurement of N2adsorption–desorption. Electron diffraction and high-resolution transmission electron microscopic (TEM) images of the nanoparticles showed the highly crystalline nature of the IONP structures. Nitrogen adsorption indicates microporous and blocked-microporous structures for the silica-coated and amine functionalized silica-coated IONP, respectively which could prove less cytotoxicity of the functionalized final product. Besides, the colloidal stability of the final product and the presence of the modified functional groups on top of surface layer have been proven by zeta-potential measurements. Owing to the benefit from the inner IONP core and the hydrophilic silica shell, the as-synthesized nanocomposites were exploited as an MRI contrast enhancement agent. Relaxometric results prove that the surface functionalized IONP have also signal enhancement properties. These surface functionalized nanocomposites are not only potential candidates for highly efficient contrast agents for MRI, but could also be used as ultrasensitive biological-magnetic labels, because they are in nanoscale size, having magnetic properties, blocked-microporous and are well dispersible in biological environment.
通过噻吩的电化学氧化聚合在电极上轻松沉积[60]富勒烯。
影响因子：
4.9
作者：
Tsukasa Hatano;M. Takeuchi;A. Ikeda;S. Shinkai
通讯作者：
S. Shinkai
影响因子：
15
作者：
Sun, SH;Zeng, H;Li, GX
通讯作者：
Li, GX