Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.
Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.
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鞘氨醇激酶1通过调节流感病毒感染后的病毒RNA合成和病毒核糖核蛋白复合物的核输出来作为促病毒因子。
DOI：
10.1371/journal.pone.0075005
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hahm B
中科院分区：
文献类型：
--
作者：
Seo YJ;Pritzl CJ;Vijayan M;Bomb K;McClain ME;Alexander S;Hahm B
Influenza continues to pose a threat to humans by causing significant morbidity and mortality. Thus, it is imperative to investigate mechanisms by which influenza virus manipulates the function of host factors and cellular signal pathways. In this study, we demonstrate that influenza virus increases the expression and activation of sphingosine kinase (SK) 1, which in turn regulates diverse cellular signaling pathways. Inhibition of SK suppressed virus-induced NF-κB activation and markedly reduced the synthesis of viral RNAs and proteins. Further, SK blockade interfered with activation of Ran-binding protein 3 (RanBP3), a cofactor of chromosome region maintenance 1 (CRM1), to inhibit CRM1-mediated nuclear export of the influenza viral ribonucleoprotein complex. In support of this observation, SK inhibition altered the phosphorylation of ERK, p90RSK, and AKT, which is the upstream signal of RanBP3/CRM1 activation. Collectively, these results indicate that SK is a key pro-viral factor regulating multiple cellular signal pathways triggered by influenza virus infection.
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RanBP3 独立于 CRM1 增强活性 (β)-连环蛋白的核输出。
影响因子：
7.8
作者：
Hendriksen, J;Fagotto, F;van der Velde, H;van Schie, M;Noordermeer, J;Fornerod, M
通讯作者：
Fornerod, M
影响因子：
88.1
作者：
Medina, Rafael A.;Garcia-Sastre, Adolfo
通讯作者：
Garcia-Sastre, Adolfo
影响因子：
5.4
作者：
Bui, M;Wills, EG;Whittaker, GR
通讯作者：
Whittaker, GR
影响因子：
5.4
作者：
Medigeshi, Guruprasad R.;Hirsch, Alec J.;Nelson, Jay A.
通讯作者：
Nelson, Jay A.
DOI：
10.1083/jcb.153.7.1391
发表时间：
2001-06-25
期刊：
The Journal of cell biology
影响因子：
--
作者：
Lindsay ME;Holaska JM;Welch K;Paschal BM;Macara IG
通讯作者：
Macara IG