The immune interplay between the host and the pathogen in Aspergillus fumigatus lung infection.
The immune interplay between the host and the pathogen in Aspergillus fumigatus lung infection.
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DOI：
10.1155/2013/693023
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发表时间：
2013
影响因子：
--
通讯作者：
Kress MR
中科院分区：
文献类型：
--
作者：
Sales-Campos H;Tonani L;Cardoso CR;Kress MR
烟曲霉菌与肺部感染中宿主免疫应答之间的相互作用由于其在免疫功能低下患者中的重要性而在过去几年中一直是研究的主题。对A.烟曲霉的致病性与真菌的生物学特性有关，例如结构、生长和适应高温和胁迫条件的能力，以及逃避免疫系统和对宿主造成损害的能力。在这种情况下，当病原体破坏自然和化学屏障，随后激活获得性免疫时，宿主先天免疫对真菌的识别发生。似乎很明显，Th1反应具有保护作用，而Th2反应通常与较高的真菌负荷相关，而Th17反应仍有争议。此外，需要精细调节效应免疫以避免与真菌清除相关的过度组织损伤，并且这种作用可归因于调节性T细胞。最后，在这项工作中，我们回顾了宿主免疫反应和病原体毒力因子之间复杂的相互作用所涉及的方面，强调了免疫学问题及其更好地理解侵袭性肺曲霉病新的治疗方法的发展的重要性。
The interplay between Aspergillus fumigatus and the host immune response in lung infection has been subject of studies over the last years due to its importance in immunocompromised patients. The multifactorial virulence factors of A. fumigatus are related to the fungus biological characteristics, for example, structure, ability to grow and adapt to high temperatures and stress conditions, besides capability of evading the immune system and causing damage to the host. In this context, the fungus recognition by the host innate immunity occurs when the pathogen disrupts the natural and chemical barriers followed by the activation of acquired immunity. It seems clear that a Th1 response has a protective role, whereas Th2 reactions are often associated with higher fungal burden, and Th17 response is still controversial. Furthermore, a fine regulation of the effector immunity is required to avoid excessive tissue damage associated with fungal clearance, and this role could be attributed to regulatory T cells. Finally, in this work we reviewed the aspects involved in the complex interplay between the host immune response and the pathogen virulence factors, highlighting the immunological issues and the importance of its better understanding to the development of novel therapeutic approaches for invasive lung aspergillosis.
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影响因子：
6.7
作者：
Bruns S;Kniemeyer O;Hasenberg M;Aimanianda V;Nietzsche S;Thywissen A;Jeron A;Latgé JP;Brakhage AA;Gunzer M
通讯作者：
Gunzer M
影响因子：
3.1
作者：
AMITANI, R;TAYLOR, G;WILSON, R
通讯作者：
WILSON, R
影响因子：
4.4
作者：
Bozza, Silvia;Clavaud, Cecile;Romani, Luigina
通讯作者：
Romani, Luigina
影响因子：
20.3
作者：
Beck, O;Topp, MS;Lehrnbecher, T
通讯作者：
Lehrnbecher, T
影响因子：
3.1
作者：
Behnsen, Judith;Lessing, Franziska;Brakhage, Axel A.
通讯作者：
Brakhage, Axel A.