Sphingomyelin Liposomes Containing Porphyrin-phospholipid for Irinotecan Chemophototherapy.
Sphingomyelin Liposomes Containing Porphyrin-phospholipid for Irinotecan Chemophototherapy.
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DOI：
10.7150/thno.15701
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发表时间：
2016
期刊：
影响因子：
12.4
通讯作者：
Lovell JF
中科院分区：
文献类型：
--
作者：
Carter KA;Luo D;Razi A;Geng J;Shao S;Ortega J;Lovell JF
卟啉-磷脂（PoP）脂质体可以捕获抗癌药物并在近红外（NIR）光下释放抗癌药物。当阿霉素以高药脂比通过硫酸铵梯度远程加载时，会形成细长的晶体，改变脂质体的形态，无法装载到PoP含量较高的脂质体中。另一方面，伊立替康也可以远程加载，但不会形成大晶体，也不会诱导脂质体伸长。伊立替康在PoP脂质体中的装载、稳定性和近红外光触发的释放被所使用的脂质类型和聚乙二醇化的存在所改变。鞘磷脂（Sphingomyelin）先前已被探索用于伊立替康脂质体，发现其产生的脂质体具有相对改善的血清稳定性和近红外光触发的药物快速释放。活体显微镜监测到，由鞘磷脂、胆固醇和2摩尔百分比PoP组成的PoP脂质体在近红外照射下迅速释放伊立替康，并在携带MIA Paca-2皮下肿瘤异种移植的小鼠中诱导有效的肿瘤根除。
Porphyrin-phospholipid (PoP) liposomes can entrap anti-cancer agents and release them in response to near infrared (NIR) light. Doxorubicin, when remotely loaded via an ammonium sulfate gradient at a high drug-to-lipid ratio, formed elongated crystals that altered liposome morphology and could not be loaded into liposomes with higher PoP content. On the other hand, irinotecan could also be remotely loaded but did not form large crystals and did not induce liposome elongation. The loading, stability, and NIR light-triggered release of irinotecan in PoP liposomes was altered by the types of lipids used and the presence of PEGylation. Sphingomyelin, which has been explored previously for liposomal irinotecan, was found to produce liposomes with relatively improved serum stability and rapid NIR light-triggered drug release. PoP liposomes composed from sphingomyelin, cholesterol and 2 molar percent PoP rapidly released irinotecan in vivo in response to NIR irradiation as monitored by intravital microscopy and also induced effective tumor eradication in mice bearing MIA Paca-2 subcutaneous tumor xenografts.
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影响因子：
4.9
作者：
Carter KA;Wang S;Geng J;Luo D;Shao S;Lovell JF
通讯作者：
Lovell JF
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影响因子：
48
作者：
Li, Xueming;Mooney, Paul;Zheng, Shawn;Booth, Christopher R.;Braunfeld, Michael B.;Gubbens, Sander;Agard, David A.;Cheng, Yifan
通讯作者：
Cheng, Yifan
影响因子：
14
作者：
Luo D;Carter KA;Razi A;Geng J;Shao S;Giraldo D;Sunar U;Ortega J;Lovell JF
通讯作者：
Lovell JF
影响因子：
15.9
作者：
Krauze, Michal T.;Noble, Charles O.;Bankiewicz, Krystof S.
通讯作者：
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影响因子：
2.8
作者：
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通讯作者：
Chu, IM