Understanding the Physiological Role of Electroneutral Na(+)-Coupled HCO(3)(-) Cotransporter and Its Therapeutic Implications.
Understanding the Physiological Role of Electroneutral Na(+)-Coupled HCO(3)(-) Cotransporter and Its Therapeutic Implications.
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了解电中性 Na 偶联 HCO3 协同转运蛋白的生理作用及其治疗意义
DOI：
10.3390/ph15091082
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发表时间：
2022-08-30
期刊：
影响因子：
--
通讯作者：
Wu J
中科院分区：
文献类型：
--
作者：
Wang J;Zahra A;Wang Y;Wu J
酸碱平衡对正常的生理功能和病理至关重要。SLC4家族的HCO3 -跨膜共转运体是HCO3 -跨膜转运载体之一，在上皮细胞中负责细胞pH调节和HCO3 -的摄取或分泌。NBCn1 （SLC4A7）是一种电中性的Na+/HCO3−共转运蛋白，在多种组织中广泛表达，并在细胞酸化后作为净酸挤压的共转运蛋白。然而，NBCn1的表达和活性水平尚不清楚。此外，NBCn1还参与了许多其他细胞过程，如细胞体积、细胞死亡/生存平衡、上皮转运以及细胞活力的调节。本文综述了NBCn1的最新研究进展，重点介绍了NBCn1转运体的基本特征、调控、组织特异性生理以及有效的NBCn1转运体抑制剂在癌症治疗中的开发和应用。应针对NBCn1及其相关通路开展靶向治疗的研究和开发。
Acid–base homeostasis is critical for proper physiological function and pathology. The SLC4 family of HCO3− transmembrane cotransporters is one of the HCO3− transmembrane transport carriers responsible for cellular pH regulation and the uptake or secretion of HCO3− in epithelial cells. NBCn1 (SLC4A7), an electroneutral Na+/HCO3− cotransporter, is extensively expressed in several tissues and functions as a cotransporter for net acid extrusion after cellular acidification. However, the expression and activity level of NBCn1 remain elusive. In addition, NBCn1 has been involved in numerous other cellular processes such as cell volume, cell death/survival balance, transepithelial transport, as well as regulation of cell viability. This review aims to give an inclusive overview of the most recent advances in the research of NBCn1, emphasizing the basic features, regulation, and tissue-specific physiology as well as the development and application of potent inhibitors of NBCn1 transporter in cancer therapy. Research and development of targeted therapies should be carried out for NBCn1 and its associated pathways.
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影响因子：
2.7
作者：
Choi, Inyeong;Beedholm, Kristian;Dam, Vibeke S.;Bae, Seong-Ho;Noble, Donald J.;Garraway, Sandra M.;Aalkjaer, Christian;Boedtkjer, Ebbe
通讯作者：
Boedtkjer, Ebbe
DOI：
10.1111/j.1460-9568.2008.06611.x
发表时间：
2009-02
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Cooper DS;Yang HS;He P;Kim E;Rajbhandari I;Yun CC;Choi I
通讯作者：
Choi I
影响因子：
10.8
作者：
Boedtkjer, Ebbe;Bentzon, Jacob F.;Aalkjaer, Christian
通讯作者：
Aalkjaer, Christian
影响因子：
64.8
作者：
Choi, I;Aalkjaer, C;Boron, WF
通讯作者：
Boron, WF
影响因子：
5.5
作者：
Chen, Mingmin;Praetorius, Jeppe;Seidler, Ursula
通讯作者：
Seidler, Ursula