Assessment of intramyocardial hemorrhage with dark-blood T2*-weighted cardiovascular magnetic resonance.
Assessment of intramyocardial hemorrhage with dark-blood T2*-weighted cardiovascular magnetic resonance.
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DOI：
10.1186/s12968-021-00787-4
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发表时间：
2021-07-15
期刊：
影响因子：
--
通讯作者：
Dharmakumar R
中科院分区：
文献类型：
--
作者：
Guan X;Chen Y;Yang HJ;Zhang X;Ren D;Sykes J;Butler J;Han H;Zeng M;Prato FS;Dharmakumar R
心肌梗死（MI）中的心肌内出血（IMH）与主要不良心血管事件相关。基于全血T2* 的心血管磁共振（CMR）已成为非侵入性IMH检测的参考标准。尽管如此，在IMH检测的临床和临床前环境中，基于暗血T2 * 的CMR正在与亮血T2* 加权CMR互换使用。然而，到目前为止，还没有研究暗血T2* 加权相对于亮血T2* 加权CMR的IMH表征的相对优点。我们研究了暗血T2* 加权CMR对亮血T2 * 加权CMR在临床和临床前环境中IMH表征的诊断能力。出血性心肌梗死患者（n = 20）和犬（n = 11）在急性和慢性期在1.5和3 T下进行了深色和明亮的血液T2* 加权CMR成像。评估了暗血T2 * 加权CMR相对于亮血T2 * 加权CMR用于IMH表征的成像特征（相对信噪比（SNR）、相对对比度噪声（CNR）、IMH程度）和诊断性能（灵敏度、特异性、准确度、曲线下面积和观察者间变异性）。在临床和临床前环境中，与亮血T2* 加权CMR相比，暗血T2* 加权图像具有显著较低的SNR、CNR和降低的IMH程度（所有p < 0.05）。与亮血T2 * 加权CMR相比，暗血T2 * 加权CMR的敏感性、特异性、准确性和观察者间变异性也较弱（所有p < 0.05）。这些观察结果在梗死年龄和成像场强之间是一致的。虽然IMH在暗血T2* 加权CMR上可见，但在1.5和3 T下，在临床和临床前环境中，IMH的整体显著性与亮血T2* 加权图像中观察到的相比显著降低。因此，亮血T2* 加权CMR更适合临床使用，因为暗血T2* 加权CMR可能将出血性MI错误分类为非出血性MI。
Intramyocardial hemorrhage (IMH) within myocardial infarction (MI) is associated with major adverse cardiovascular events. Bright-blood T2*-based cardiovascular magnetic resonance (CMR) has emerged as the reference standard for non-invasive IMH detection. Despite this, the dark-blood T2*-based CMR is becoming interchangeably used with bright-blood T2*-weighted CMR in both clinical and preclinical settings for IMH detection. To date however, the relative merits of dark-blood T2*-weighted with respect to bright-blood T2*-weighted CMR for IMH characterization has not been studied. We investigated the diagnostic capacity of dark-blood T2*-weighted CMR against bright-blood T2*-weighted CMR for IMH characterization in clinical and preclinical settings. Hemorrhagic MI patients (n = 20) and canines (n = 11) were imaged in the acute and chronic phases at 1.5 and 3 T with dark- and bright-blood T2*-weighted CMR. Imaging characteristics (Relative signal-to-noise (SNR), Relative contrast-to-noise (CNR), IMH Extent) and diagnostic performance (sensitivity, specificity, accuracy, area-under-the-curve, and inter-observer variability) of dark-blood T2*-weighted CMR for IMH characterization were assessed relative to bright-blood T2*-weighted CMR. At both clinical and preclinical settings, compared to bright-blood T2*-weighted CMR, dark-blood T2*-weighted images had significantly lower SNR, CNR and reduced IMH extent (all p < 0.05). Dark-blood T2*-weighted CMR also demonstrated weaker sensitivity, specificity, accuracy, and inter-observer variability compared to bright-blood T2*-weighted CMR (all p < 0.05). These observations were consistent across infarct age and imaging field strengths. While IMH can be visible on dark-blood T2*-weighted CMR, the overall conspicuity of IMH is significantly reduced compared to that observed in bright-blood T2*-weighted images, across infarct age in clinical and preclinical settings at 1.5 and 3 T. Hence, bright-blood T2*-weighted CMR would be preferable for clinical use since dark-blood T2*-weighted CMR carries the potential to misclassify hemorrhagic MIs as non-hemorrhagic MIs.
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DOI：
10.1186/s12968-017-0389-8
发表时间：
2017-10-09
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Messroghli DR;Moon JC;Ferreira VM;Grosse-Wortmann L;He T;Kellman P;Mascherbauer J;Nezafat R;Salerno M;Schelbert EB;Taylor AJ;Thompson R;Ugander M;van Heeswijk RB;Friedrich MG
通讯作者：
Friedrich MG
DOI：
10.1161/circimaging.113.001541
发表时间：
2014-05
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Kali A;Cokic I;Tang RL;Yang HJ;Sharif B;Marbán E;Li D;Berman DS;Dharmakumar R
通讯作者：
Dharmakumar R
影响因子：
19.7
作者：
Kali, Avinash;Tang, Richard L. Q.;Dharmakumar, Rohan
通讯作者：
Dharmakumar, Rohan
影响因子：
14
作者：
Kumar, Andreas;Green, Jordin D.;Friedrich, Matthias G.
通讯作者：
Friedrich, Matthias G.
影响因子：
3.3
作者：
Liguori, Carlo;Di Giampietro, Ilenia;Zobel, Bruno Beomonte
通讯作者：
Zobel, Bruno Beomonte