MicroRNAome genome: a treasure for cancer diagnosis and therapy.
MicroRNAome genome: a treasure for cancer diagnosis and therapy.
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DOI：
10.3322/caac.21244
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Calin GA
中科院分区：
文献类型：
--
作者：
Berindan-Neagoe I;Monroig Pdel C;Pasculli B;Calin GA
蛋白质编码基因和microRNAs(MiRNAs)基因异常之间的相互作用是过去十年肿瘤学中最令人兴奋但意想不到的发现之一。这个网络的复杂性重新定义了癌症研究，因为这些从曾经被认为是“基因组垃圾”中产生的分子，已被证明对癌症的启动、发展和传播至关重要。自然产生的miRNAs是一种非常短的转录本，从不产生蛋白质或氨基酸链，但在转录、转录后和/或翻译水平上通过调节细胞生长、发育和分化等过程中的蛋白质表达来发挥作用。在这篇综述文章中，我们介绍了miRNAs作为参与所有癌症特征的无处不在的参与者。我们还介绍了检测它们表达的最常用的方法，这些方法已经通过基因表达研究揭示了数百个在癌细胞或肿瘤微环境细胞中调控异常的miRNAs的身份。此外，我们还讨论了miRNAs作为激素以及作为可靠的癌症生物标志物和治疗反应预测因子的作用。此外，我们还探讨了设计miRNA靶向疗法的当前策略，以及研究预期要克服的相关挑战。最后，我们介绍了分子肿瘤学翻译研究的新浪潮--长非编码RNA的研究。
The interplay between abnormalities in genes coding for proteins and microRNAs (miRNAs) has been among the most exiting yet unexpected discoveries in oncology over the last decade. The complexity of this network has redefined cancer research as these molecules produced from what was once considered “genomic trash”, have shown to be crucial for cancer initiation, progression, and dissemination. Naturally occurring miRNAs are very short transcripts that never produce a protein or amino acid chain, but act by regulating protein expression during cellular processes such as growth, development and differentiation at the transcriptional, post-transcriptional and/or translational level. In this review article we present miRNAs as ubiquitous players involved in all cancer hallmarks. We also describe the most used methods to detect their expression, which have revealed through gene expression studies the identity of hundreds of miRNAs dysregulated in cancer cells or tumor microenvironment cells. Furthermore, we discuss the role of miRNAs as hormones and as reliable cancer biomarkers and predictors of treatment-response. Along with this, we explore current strategies in designing miRNA-targeting therapeutics, as well as the associated challenges that research envisions to overcome. Finally, we introduce a new wave in molecular oncology translational research, the study of long non-coding RNAs.
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DOI：
10.1126/science.1240925
发表时间：
2013-08-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Carpenter S;Aiello D;Atianand MK;Ricci EP;Gandhi P;Hall LL;Byron M;Monks B;Henry-Bezy M;Lawrence JB;O'Neill LA;Moore MJ;Caffrey DR;Fitzgerald KA
通讯作者：
Fitzgerald KA
DOI：
10.1073/pnas.0800121105
发表时间：
2008-04-01
影响因子：
11.1
作者：
Calin, George A.;Cimmino, Amelia;Croce, Carlo M.
通讯作者：
Croce, Carlo M.
影响因子：
5.7
作者：
Blower, Paul E.;Verducci, Joseph S.;Sadee, Wolfgang
通讯作者：
Sadee, Wolfgang
影响因子：
82.9
作者：
Bonci, Desiree;Coppola, Valeria;De Maria, Ruggero
通讯作者：
De Maria, Ruggero
影响因子：
15.9
作者：
Baraniskin, Alexander;Kuhnhenn, Jan;Schroers, Roland
通讯作者：
Schroers, Roland