Conversion Therapy for Advanced Pancreatic Cancer: The Case Series and Literature Review.
Conversion Therapy for Advanced Pancreatic Cancer: The Case Series and Literature Review.
复制标题
晚期胰腺癌的转换治疗：病例系列和文献综述
DOI：
10.3389/fphar.2020.579239
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发表时间：
2020
影响因子：
5.6
通讯作者：
Huang D
中科院分区：
文献类型：
--
作者：
Wang M;Xu Y;Yang M;Jiang D;Chen Y;Jiang J;Chen Z;Yang L;Huang D
胰腺癌的发病率和死亡率都很高。大多数患者在最初诊断时已处于晚期，单次手术无法治愈。ASCO临床实践指南强调整体管理和多学科综合治疗，提出了转换治疗的概念。本文通过现实世界的观察研究，探讨化疗在晚期胰腺癌患者中的转化效果及其长期生存。方法以2015 - 2019年在浙江省人民医院肿瘤科就诊的晚期胰腺癌患者为研究对象。收集汇总病例，选取5例有代表性的患者进行分析，均接受标准治疗（FOLFIRINOX、AS、AG、GS）。结合相关文献，对这些患者转换治疗后的进展、临床评价、不良反应及预后进行分析和讨论。结果5例晚期胰腺癌患者接受转化治疗，平均生存期29.8个月，其中2例接受手术治疗，术后评价病理完全缓解（pCR）。5例患者化疗耐受性良好，未发生严重3、4级不良反应。结论转化治疗为晚期胰腺癌患者争取手术根治性切除的机会，延长生存期，提高生活质量。
Background Pancreatic cancer has a high incidence and mortality. Most patients are in an advanced stage at the time of initial diagnosis and cannot be cured by a single surgery. The ASCO clinical practice guideline emphasized the overall management and multidisciplinary comprehensive treatment which put forward the concept of conversion therapy. In this paper, the real-world observation and study were carried out to explore the conversion effect of chemotherapy in patients with advanced pancreatic cancer and their long-term survival. Methods The subjects of this study are advanced pancreatic cancer patients who visited the oncology department of Zhejiang Provincial People’s Hospital from 2015 to 2019. Collected and summarized the cases, and selected 5 representative patients for analysis, all of them received standard treatment (FOLFIRINOX, AS, AG, or GS). The progress, clinical evaluation, adverse reactions, and prognosis of these patients after conversion therapy were analyzed and discussed in conjunction with relevant literature. Results Five patients with advanced pancreatic cancer received conversion therapy with an average survival time of 29.8 months, two of them received surgical treatment, and postoperative evaluations were pathological complete response (pCR). The tolerance of chemotherapy was good in five patients, and no serious adverse reactions of grade 3 or 4 occurred. Conclusion Conversion therapy for patients with advanced pancreatic cancer strives for surgical opportunities of radical resection, prolongs survival and improves quality of life.
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影响因子：
5.8
作者：
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通讯作者：
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