Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease.
Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease.
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DOI：
10.1111/jdi.12026
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发表时间：
2013-05
影响因子：
3.2
通讯作者：
Inoue S
中科院分区：
文献类型：
--
作者：
Katagiri S;Nitta H;Nagasawa T;Izumi Y;Kanazawa M;Matsuo A;Chiba H;Fukui M;Nakamura N;Oseko F;Kanamura N;Inagaki K;Noguchi T;Naruse K;Matsubara T;Miyazaki S;Miyauchi T;Ando Y;Hanada N;Inoue S
糖尿病与牙周炎密切相关。已有大量报告指出牙周干预治疗对血糖控制的影响，但尚无报告说明血糖干预治疗对2型糖尿病患者牙周疾病的影响。这项研究的目的是检验通过血糖干预治疗改善血糖控制对2型糖尿病患者牙周炎的影响。共有35名患者在没有牙周治疗的情况下接受了干预治疗以改善血糖控制。分别于基线、干预治疗后2个月和6个月检测糖化血红蛋白(HbA1c)、超敏C反应蛋白(hs-CRP)、探诊出血(BOP)、探诊袋深度(PPD)和口腔内社区牙周指数(CPI)编码，以改善血糖控制。血糖控制改善后，BOP损害改善，但深度PPD损害和WHO CPI编码没有改善。子分析显示，有效的血糖控制(平均HbA1c降低1.8%)改善了BOP损害，但不影响深度PPD损害和WHO CPI编码。此外，基线水平的高BOP病变对血糖干预的反应更有效。对35名患者进行的独立于WHO CPI编码的所有牙周部位CPI编码的进一步分析表明，在进行血糖干预后，只有牙周炎而不是牙周袋较深的情况有所改善。有效的血糖控制通过改善牙周组织牙龈部位的炎症来改善患有牙周炎的2型糖尿病患者的BOP损害。这项试验是在大学医院医学信息网(No.UMIN000007670)。
Diabetes mellitus and periodontitis are closely related. A huge number of reports has addressed the effect of periodontal intervention therapy on glycemic control, but no reports have addressed the effect of glycemic intervention therapy on periodontal disease in type 2 diabetic patients. The aim of this study was to examine the effect of improved glycemic control by glycemic intervention therapy on periodontitis in type 2 diabetic patients. A total of 35 patients underwent intervention therapy to improve glycemic control without periodontal treatment. Glycohemoglobin (HbA1c), high‐sensitivity C‐reactive protein (hs‐CRP), bleeding on probing (BOP), probing pocket depth (PPD) and intraoral community periodontal index (CPI) codes of the World health Organization (WHO) were examined at baseline, and 2 and 6 months after the intervention therapy to improve glycemic control. After the improvement of glycemic control, BOP lesions improved, but deep PPD lesions and WHO CPI codes did not improve. Subanalyses showed that effective glycemic control (average HbA1c reduction 1.8%) improved BOP lesions, but did not affect deep PPD lesions and WHO CPI codes. In addition, high BOP lesions at baseline responded more effectively to glycemic intervention. Further analysis of CPI codes in all individual periodontal sites independent of WHO CPI codes in 35 patients showed that only gingival inflammation without a deep periodontal pocket improved after glycemic intervention. Effective glycemic control improves BOP lesions in type 2 diabetic patients with periodontitis through ameliorating inflammation at the gingival sites of periodontal tissue. This trial was registered with the University Hospital Medical Information Network (no. UMIN000007670).
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影响因子：
4.3
作者：
King, George L.
通讯作者：
King, George L.
影响因子：
16.2
作者：
Shultis, Wendy A.;Weil, E. Jennifer;Nelson, Robert G.
通讯作者：
Nelson, Robert G.
影响因子：
6.7
作者：
SASTROWIJOTO, SH;HILLEMANS, P;DEGRAAFF, J
通讯作者：
DEGRAAFF, J
影响因子：
6.7
作者：
Stewart, JE;Wager, KA;Zadeh, HH
通讯作者：
Zadeh, HH
影响因子：
18.6
作者：
Page, RC;Offenbacher, S;Kornman, KS
通讯作者：
Kornman, KS