Advances in the techniques for the prediction of microRNA targets.

Advances in the techniques for the prediction of microRNA targets.
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microRNA靶标预测技术的进展

DOI:
10.3390/ijms14048179
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发表时间:
2013-04-15
影响因子:
5.6
通讯作者:
Jiang SW
Jiang SW
中科院分区:
生物学2区
文献类型:
--
作者:
Zheng H;Fu R;Wang JT;Liu Q;Chen H;Jiang SW

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microRNA(miRNAs)是一类非编码的内源性小分子RNA,通过转录后调节靶基因的表达,在多种正常和疾病的生物学过程中发挥重要作用。它们可以与蛋白质编码基因的靶信使RNA(mRNA)转录物结合,并负控制其翻译或引起mRNA降解。已经发现miRNA积极地调节多种细胞过程,包括细胞增殖、死亡和代谢。因此,它们的研究对于更好地理解真核生物的细胞功能至关重要。为了更好地理解miRNA:mRNA相互作用的机制及其细胞功能,准确识别miRNA靶点是重要的。本文就动物miRNA靶点预测方法的研究进展及现有的研究资源进行综述,为进一步研究miRNA及其功能提供参考。
MicroRNAs (miRNAs) are small, non-coding, endogenous RNA molecules that play important roles in a variety of normal and diseased biological processes by post-transcriptionally regulating the expression of target genes. They can bind to target messenger RNA (mRNA) transcripts of protein-coding genes and negatively control their translation or cause mRNA degradation. miRNAs have been found to actively regulate a variety of cellular processes, including cell proliferation, death, and metabolism. Therefore, their study is crucial for the better understanding of cellular functions in eukaryotes. To better understand the mechanisms of miRNA: mRNA interaction and their cellular functions, it is important to identify the miRNA targets accurately. In this paper, we provide a brief review for the advances in the animal miRNA target prediction methods and available resources to facilitate further study of miRNAs and their functions.
DOI: 10.1186/1471-2105-12-300
发表时间: 2011-07-26
期刊: BMC bioinformatics
影响因子: 3
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