Prefrontal cortical deficits and impaired cognition-emotion interactions in schizophrenia.
Prefrontal cortical deficits and impaired cognition-emotion interactions in schizophrenia.
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精神分裂症的前额叶皮质缺陷和认知情感相互作用受损。
DOI：
10.1176/appi.ajp.2010.09081215
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Carter CS
中科院分区：
文献类型：
--
作者：
Ursu S;Kring AM;Gard MG;Minzenberg MJ;Yoon JH;Ragland JD;Solomon M;Carter CS
尽管精神分裂症患者在访谈和自我报告测量中报告情绪体验减少，但他们在情绪刺激和日常生活中的情绪体验（“当下”）似乎基本完好无损。为了检验情绪-认知相互作用，作者测试了一种假设，即精神分裂症患者的即时情绪反应没有受损，但前额叶皮层机制存在缺陷，而前额叶皮层机制需要在暴露于情绪刺激后维持和报告经验。研究人员使用慢速事件相关的功能性核磁共振成像（MRI）范式，对23名精神分裂症患者和24名健康对照者的大脑活动进行了检查。在试验中，他们观看了一张情感图片，并在一段时间后报告了他们在观看时的情感体验。当患者在与刺激效价不一致的维度上评价自己的体验时，他们的情绪体验自我报告与健康受试者的不同，而在与刺激效价一致的维度上评价自己的体验时，他们的情绪体验自我报告与健康受试者的不同。在情绪刺激下，患者的大脑活动与对照组相似。然而，在延迟期间，患者表现出大脑结构网络的激活减少，包括背外侧前额叶皮层和其他前额叶、边缘和旁边缘区。在患者中，背外侧前额叶皮层对愉快刺激的延迟相关反应与快感缺乏测量呈负相关。这些结果表明，精神分裂症的特征是支持情绪和目标导向行为之间联系的前额叶电路的失败，这种机制的失败可能导致情绪-认知相互作用相关过程的缺陷。
Despite schizophrenia patients’ reports of diminished experience of emotion in interviews and self-report measures, their emotional experience in the presence of emotional stimuli and in daily life (“in the moment”) appears largely intact. To examine emotion-cognition interactions, the authors tested the hypothesis that schizophrenia patients have unimpaired in-the-moment emotional reactivity but have a deficit in prefrontal cortical mechanisms needed to maintain and report on experience following exposure to emotional stimuli. Using a slow event-related functional MRI paradigm, the authors examined the brain activity of 23 schizophrenia patients and 24 healthy comparison subjects during trials in which they viewed an affective picture and, after a delay, reported their emotional experience while viewing it. The patients’ self-reports of emotional experience differed from those of the healthy subjects when they rated their experience on dimensions inconsistent with the stimulus valence but not when the dimension was consistent with it. In the presence of emotional stimuli, brain activity in the patients was similar to that of the comparison subjects. During the delay, however, patients showed decreased activation in a network of brain structures, including the dorsolateral prefrontal cortex and other prefrontal, limbic, and paralimbic areas. In patients, the delay-related response of the dorsolateral prefrontal cortex to pleasant stimuli correlated negatively with an anhedonia measure. These results suggest that schizophrenia is characterized by a failure of prefrontal circuitry supporting the link between emotion and goal-directed behavior and that the failure of this mechanism may contribute to deficits in processes related to emotion-cognition interaction.
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影响因子：
10.6
作者：
Dowd, Erin C.;Barch, Deanna M.
通讯作者：
Barch, Deanna M.
DOI：
10.1073/pnas.0306408101
发表时间：
2004-03-02
影响因子：
11.1
作者：
Kensinger, EA;Corkin, S
通讯作者：
Corkin, S
影响因子：
4.6
作者：
Heerey, Erin A.;Gold, James M.
通讯作者：
Gold, James M.
影响因子：
3.7
作者：
Kring, AM;Kerr, SL;Earnst, KS
通讯作者：
Earnst, KS
影响因子：
4.6
作者：
Gold, James M.;Fuller, Rebecca L.;Luck, Steven J.
通讯作者：
Luck, Steven J.