Sulforaphane's Multifaceted Potential: From Neuroprotection to Anticancer Action.
Sulforaphane's Multifaceted Potential: From Neuroprotection to Anticancer Action.
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DOI：
10.3390/molecules28196902
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发表时间：
2023-10-01
期刊：
影响因子：
--
通讯作者：
Allen AR
中科院分区：
文献类型：
--
作者：
Otoo RA;Allen AR
萝卜硫素（SFN）是一种天然存在的化合物，存在于十字花科蔬菜如花椰菜和花椰菜中。它作为一种神经保护剂和抗癌剂的潜力已被广泛研究。本文旨在批判性地评估目前支持SFN神经保护和抗癌作用的证据，以及SFN发挥这些作用的潜在机制。SFN已被证明通过激活Nrf2通路、调节神经炎症和表观遗传机制发挥神经保护作用。在癌症治疗中，SFN已经证明能够选择性地诱导癌细胞的细胞死亡，抑制组蛋白脱乙酰酶，并使癌细胞对化疗敏感。SFN还通过抑制I相代谢酶、调节II相异生物质代谢酶和靶向癌症干细胞显示出化学保护特性。除了其作为神经系统疾病和癌症治疗的治疗剂的潜力外，SFN还显示出作为脑缺血性损伤和颅内出血的潜在治疗的前景。最后，正在进行和完成的SFN临床试验表明了潜在的治疗益处，但需要更多的研究来确定其有效性。总的来说，SFN作为具有多种治疗应用的天然化合物具有重要的前景。
Sulforaphane (SFN) is a naturally occurring compound found in cruciferous vegetables such as broccoli and cauliflower. It has been widely studied for its potential as a neuroprotective and anticancer agent. This review aims to critically evaluate the current evidence supporting the neuroprotective and anticancer effects of SFN and the potential mechanisms through which it exerts these effects. SFN has been shown to exert neuroprotective effects through the activation of the Nrf2 pathway, the modulation of neuroinflammation, and epigenetic mechanisms. In cancer treatment, SFN has demonstrated the ability to selectively induce cell death in cancer cells, inhibit histone deacetylase, and sensitize cancer cells to chemotherapy. SFN has also shown chemoprotective properties through inhibiting phase I metabolizing enzymes, modulating phase II xenobiotic-metabolizing enzymes, and targeting cancer stem cells. In addition to its potential as a therapeutic agent for neurological disorders and cancer treatment, SFN has shown promise as a potential treatment for cerebral ischemic injury and intracranial hemorrhage. Finally, the ongoing and completed clinical trials on SFN suggest potential therapeutic benefits, but more research is needed to establish its effectiveness. Overall, SFN holds significant promise as a natural compound with diverse therapeutic applications.
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