Nuclear filaments: role in chromosomal positioning and gene expression.
Nuclear filaments: role in chromosomal positioning and gene expression.
复制标题
DOI：
10.1080/19491034.2020.1769445
复制
发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Sengupta K
中科院分区：
文献类型：
--
作者：
Bera M;Sengupta K
核纤层在内核膜下形成弹性网络，为细胞核提供机械刚性并保持形状。核纤层蛋白还维持染色体定位，并在几个核过程中发挥重要作用，如复制，DNA损伤修复，转录和表观遗传修饰。LMNA突变影响心脏组织、肌肉组织、脂肪组织，以促成统称为核纤层蛋白病的几种疾病。然而，LMNA突变和核纤层蛋白病背后的原理仍然困扰着科学家。在间期，几条染色体在核质内形成染色体间/染色体内接触，几个染色体环也伸展形成“环簇”，这是调节基因表达的关键参与者。从这个角度来看，我们已经提出，核纤层蛋白网络与核肌动蛋白和肌球蛋白串联提供机械刚度的染色体接触，并促进环簇运动。因此，LMNA突变可能会扰乱染色体接触或环簇定位的景观，这可能会损害基因表达谱。
Nuclear lamins form an elastic meshwork underlying the inner nuclear membrane and provide mechanical rigidity to the nucleus and maintain shape. Lamins also maintain chromosome positioning and play important roles in several nuclear processes like replication, DNA damage repair, transcription, and epigenetic modifications. LMNA mutations affect cardiac tissue, muscle tissues, adipose tissues to precipitate several diseases collectively termed as laminopathies. However, the rationale behind LMNA mutations and laminopathies continues to elude scientists. During interphase, several chromosomes form inter/intrachromosomal contacts inside nucleoplasm and several chromosomal loops also stretch out to make a ‘loop-cluster’ which are key players to regulate gene expressions. In this perspective, we have proposed that the lamin network in tandem with nuclear actin and myosin provide mechanical rigidity to the chromosomal contacts and facilitate loop-clusters movements. LMNA mutations thus might perturb the landscape of chromosomal contacts or loop-clusters positioning which can impair gene expression profile.
登录
查看更多内容
影响因子：
7.2
作者：
Barlan K;Gelfand VI
通讯作者：
Gelfand VI
影响因子：
2.9
作者：
Bhattacharjee, Pritha;Banerjee, Avinanda;Sengupta, Kaushik
通讯作者：
Sengupta, Kaushik
影响因子：
3.7
作者：
Banerjee A;Rathee V;Krishnaswamy R;Bhattacharjee P;Ray P;Sood AK;Sengupta K
通讯作者：
Sengupta K
影响因子：
16
作者：
de Wit, Elzo;Vos, Erica S. M.;de laat, Wouter
通讯作者：
de laat, Wouter
DOI：
10.1016/j.bbagen.2017.08.016
发表时间：
2017-11-01
影响因子：
3
作者：
Bhattacharjee, Pritha;Dasgupta, Dipak;Sengupta, Kaushik
通讯作者：
Sengupta, Kaushik