Core outcome sets and trial registries.
Core outcome sets and trial registries.
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DOI：
10.1186/s13063-015-0738-6
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发表时间：
2015-05-14
期刊：
影响因子：
2.5
通讯作者：
Williamson P
中科院分区：
文献类型：
--
作者：
Clarke M;Williamson P
注册试验的一些原因可能被认为是自私的，例如满足研究人员希望发表其最终研究结果的期刊的要求或公开试验以促进招募。注册表条目还可以帮助其他人（包括系统审稿人）了解正在进行或未发表的研究，并通过明确正在进行的研究来减少研究浪费。研究浪费的其他来源包括同一领域各试验的结果测量不一致、某些试验的重要结果数据缺失以及选择性报告结果。减少这种浪费的一种方法是使用核心成果集：针对特定健康和社会保健领域的研究的标准化成果集。这些并不限制将要测量的结果，而是提供了试验对潜在用户最有用的最低限度。我们建议 ISRCTN 等试验注册机构鼓励研究人员在其条目中注明他们对核心结果集的使用。这将有助于人们搜索试验以及担心封闭试验中选择性报告的人。试验注册可以促进这些努力，使新试验尽可能有用并减少浪费。条目中的结果部分可以提示研究人员考虑使用核心结果集，并通过链接到原始核心结果集来促进该核心结果集及其组成结果的规范。在此过程中，注册管理机构将为全球努力做出贡献，以确保试验能够解决重要的不确定性，可以纳入系统评价，并更好地实现通过改善健康和社会护理来改善健康和福祉的最终目标。
Some reasons for registering trials might be considered as self-serving, such as satisfying the requirements of a journal in which the researchers wish to publish their eventual findings or publicising the trial to boost recruitment. Registry entries also help others, including systematic reviewers, to know about ongoing or unpublished studies and contribute to reducing research waste by making it clear what studies are ongoing. Other sources of research waste include inconsistency in outcome measurement across trials in the same area, missing data on important outcomes from some trials, and selective reporting of outcomes. One way to reduce this waste is through the use of core outcome sets: standardised sets of outcomes for research in specific areas of health and social care. These do not restrict the outcomes that will be measured, but provide the minimum to include if a trial is to be of the most use to potential users. We propose that trial registries, such as ISRCTN, encourage researchers to note their use of a core outcome set in their entry. This will help people searching for trials and those worried about selective reporting in closed trials. Trial registries can facilitate these efforts to make new trials as useful as possible and reduce waste. The outcomes section in the entry could prompt the researcher to consider using a core outcome set and facilitate the specification of that core outcome set and its component outcomes through linking to the original core outcome set. In doing this, registries will contribute to the global effort to ensure that trials answer important uncertainties, can be brought together in systematic reviews, and better serve their ultimate aim of improving health and well-being through improving health and social care.
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影响因子：
3.7
作者：
Clarke M;Brice A;Chalmers I
通讯作者：
Chalmers I
影响因子：
3.7
作者：
Gargon E;Gurung B;Medley N;Altman DG;Blazeby JM;Clarke M;Williamson PR
通讯作者：
Williamson PR
影响因子：
2.5
作者：
Kirkham JJ;Boers M;Tugwell P;Clarke M;Williamson PR
通讯作者：
Williamson PR
影响因子：
--
作者：
Adams, Clive E;Polzmacher, Stefanie;Wolff, Annabelle
通讯作者：
Wolff, Annabelle
DOI：
10.1136/bmj.e7586
发表时间：
2013-01-08
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Chan AW;Tetzlaff JM;Gøtzsche PC;Altman DG;Mann H;Berlin JA;Dickersin K;Hróbjartsson A;Schulz KF;Parulekar WR;Krleza-Jeric K;Laupacis A;Moher D
通讯作者：
Moher D