Ribosome biogenesis factors-from names to functions.
Ribosome biogenesis factors-from names to functions.
复制标题
DOI：
10.15252/embj.2022112699
复制
发表时间：
2023-04-03
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
核糖体亚基的组装是一个高度精心策划的过程，涉及大量辅助因素。大多数真核核糖体生物发生因子首先是通过酿酒酵母中前核糖体颗粒的遗传筛选和蛋白质组学方法鉴定的。后来，对人类核糖体合成的研究不仅证明了对许多这些因子的需求在进化中是保守的，而且还揭示了其他参与者的参与，反映了哺乳动物细胞中更复杂的组装途径。然而，为许多已识别的因素分配功能并揭示其分子作用模式仍然是该领域的一个挑战。在过去的十年中，结构、生化和细胞研究在很大程度上填补了这一知识空白，并导致人们对核糖体成熟的逐步过程中许多参与者的分子作用有了详细的了解。对核糖体生物合成因子功能的详细了解将是进一步了解和更好地治疗与核糖体组装紊乱相关的疾病（包括核糖体病以及不同类型的癌症）的关键。作为我们 2023 年 RNA 综述系列的一部分，Kutay 及其同事提供了有关不同物种核糖体生物发生的多种因素的全面更新。
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified by genetic screens and proteomic approaches of pre‐ribosomal particles in Saccharomyces cerevisiae. Later, research on human ribosome synthesis not only demonstrated that the requirement for many of these factors is conserved in evolution, but also revealed the involvement of additional players, reflecting a more complex assembly pathway in mammalian cells. Yet, it remained a challenge for the field to assign a function to many of the identified factors and to reveal their molecular mode of action. Over the past decade, structural, biochemical, and cellular studies have largely filled this gap in knowledge and led to a detailed understanding of the molecular role that many of the players have during the stepwise process of ribosome maturation. Such detailed knowledge of the function of ribosome biogenesis factors will be key to further understand and better treat diseases linked to disturbed ribosome assembly, including ribosomopathies, as well as different types of cancer. As part of our 2023 RNA review series, Kutay and colleagues provide a comprehensive update on the diverse factors involved in ribosome biogenesis across different species.
登录
查看更多内容
影响因子：
3.7
作者：
Axt K;French SL;Beyer AL;Tollervey D
通讯作者：
Tollervey D
影响因子：
14.9
作者：
Babiano R;Badis G;Saveanu C;Namane A;Doyen A;Díaz-Quintana A;Jacquier A;Fromont-Racine M;de la Cruz J
通讯作者：
de la Cruz J
DOI：
10.1261/rna.060723.117
发表时间：
2017-09
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Silva S;Homolka D;Pillai RS
通讯作者：
Pillai RS
多个RNA相互作用将MRD1定位在90年代前小骨中小亚基伪诺特的位置。
影响因子：
14.9
作者：
Segerstolpe Å;Granneman S;Björk P;de Lima Alves F;Rappsilber J;Andersson C;Högbom M;Tollervey D;Wieslander L
通讯作者：
Wieslander L
影响因子：
14.9
作者：
Lackmann F;Belikov S;Burlacu E;Granneman S;Wieslander L
通讯作者：
Wieslander L