Specific populations of basal ganglia output neurons target distinct brain stem areas while collateralizing throughout the diencephalon.
Specific populations of basal ganglia output neurons target distinct brain stem areas while collateralizing throughout the diencephalon.
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DOI：
10.1016/j.neuron.2021.03.017
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发表时间：
2021-05-19
期刊：
影响因子：
16.2
通讯作者：
Kleinfeld D
中科院分区：
文献类型：
--
作者：
McElvain LE;Chen Y;Moore JD;Brigidi GS;Bloodgood BL;Lim BK;Costa RM;Kleinfeld D
基底神经节在调节行为中发挥着核心作用，但其向其他大脑区域的输出组织尚不完全清楚。我们研究了最大的输出核，即黑质网状部（SNr），并描述了其在小鼠体内的投射群体的组织和生理学。利用基因靶向病毒追踪和全脑解剖分析，我们确定了 40 多个 SNr 目标，其中涵盖了大约 50 倍的轴突密度范围。从体积最大的目标逆行追踪表明 SNr 包含隔离的亚群，这些亚群差异性地投射到功能不同的脑干区域。这些亚群在电生理学上是特化的，在地形上有组织，并与常见的间脑目标相关，包括运动丘脑和层内丘脑，以及桥脚核和中脑网状结构。这些发现证实，SNr 信号传导被组织为针对特定脑干目标的密集、并行输出，同时与包含大多数 SNr 轴突连接的广泛侧支分支同时存在。麦克埃尔文等人。绘制小鼠基底神经节最大输出核（黑质网状部）的完整全脑投影图。揭示了空间隔离且电生理学上不同的亚群，它们投射到不同的脑干区域，以及桥脚核和间脑目标的广泛侧支。
The basal ganglia play a central role in regulating behavior, yet the organization of their outputs to other brain areas is incompletely understood. We investigate the largest output nucleus, the substantia nigra pars reticulata (SNr), and delineate the organization and physiology of its projection populations in mice. Using genetically-targeted viral tracing and whole-brain anatomical analysis, we identify over forty SNr targets, which encompass a roughly 50-fold range of axonal densities. Retrograde tracing from the volumetrically largest targets indicates that SNr contains segregated subpopulations that differentially project to functionally distinct brainstem regions. These subpopulations are electrophysiologically specialized, topographically organized, and collateralize to common diencephalon targets, including motor and intralaminar thalamus, as well as the pedunculopontine nucleus and the midbrain reticular formation. These findings establish that SNr signaling is organized as dense, parallel outputs to specific brainstem targets, concurrent with extensive collateral branches that encompass the majority of SNr axonal boutons. McElvain et al. map the complete set of brain-wide projections from the largest output nucleus of the murine basal ganglia, the substantia nigra pars reticulata. Spatially segregated and electrophysiologically distinct subpopulations are revealed that project to different brainstem regions, along with extensive collaterals to the pedunculopontine nucleus and diencephalon targets.
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影响因子：
4.6
作者：
Bankhead P;Loughrey MB;Fernández JA;Dombrowski Y;McArt DG;Dunne PD;McQuaid S;Gray RT;Murray LJ;Coleman HG;James JA;Salto-Tellez M;Hamilton PW
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