[Psychosocial risk factors of Alzheimer's disease].
[Psychosocial risk factors of Alzheimer's disease].
复制标题
阿尔茨海默病的心理社会危险因素。
作者：
X. Zhang;C. Li;M. Zhang
客观化
探讨心理社会因素与阿尔茨海默病(AD)发病风险的关系。
方法
一项针对55岁及以上人群的队列研究在基线筛查后10年进行了跟踪调查。采用分层整群抽样方法，对上海市某区5055名老年人进行调查。有关心理社会因素的信息收集于1987年。痴呆和AD的临床诊断依据DSM-III-R和NINCDS-ADRDA标准。1997年，对4896名非痴呆者进行了跟踪调查。计算AD的发病率，用Logistic模型分析心理社会因素与AD的关系。
结果
1997年对1203名受试者进行了复查，其中发现124例新的痴呆症病例，其中包括81例阿尔茨海默病。通过计算心理社会因素对AD的相对危险度(RR)，发现许多心理社会因素与AD有关，包括蓝领职业、无工作、不阅读或写作、不参加社区活动、闲暇时不从事园艺、心理感受不良和文化程度较低(RR>；1)。PARP>；50%高的项目依次为不工作、无工作、退休、不参加社区活动、不阅读或写作、从事蓝领职业、不从事休闲园艺。MMSE总分对AD有较好的预测作用。
结论
心理社会因素在阿尔茨海默病的发展中起着重要作用。
OBJECTIVE
To explore the relationship between psychosocial factor and risk of Alzheimer's disease(AD).
METHODS
A cohort study of people 55 years and older was followed up 10 years after a baseline screening. 5,055 elderly subjects in a district of Shanghai were stratified clustering sampled from community. Information about psychosocial factors was collected in 1987. The clinical diagnoses of dementia and AD were made according to DSM-III-R and NINCDS-ADRDA criteria. 4,896 non-demented persons were followed in 1997. The incidence of AD was calculated and the relationship between the psychosocial factors and the AD was analyzed by Logistic model.
RESULTS
1,203 subjects were resurveyed in 1997 and among them 124 new cases of dementia including 81 cases of AD were identified. By computing the relative risk(RR) of psychosocial factors to the AD, many psychosocial factors were found to be correlated with AD including blue collar occupation, no job, no reading or writing, no taking community activities, no gardening in leisure, bad psychological feeling and lower education (RR > 1). The items with high PARP > 50% were not working, no job, retirement, no taking community activities, no reading or writing, blue collar occupation and no gardening in leisure. MMSE total score is a good predict for AD.
CONCLUSION
Psychosocial factors play an important role in the development of Alzheimer's disease.
DOI：
10.1001/jama.1994.03510370056032
发表时间：
1994-04
期刊：
JAMA
影响因子：
--
作者：
Y. Stern;B. Gurland;T. Tatemichi;M. Tang;D. Wilder;R. Mayeux
通讯作者：
Y. Stern;B. Gurland;T. Tatemichi;M. Tang;D. Wilder;R. Mayeux
影响因子：
--
作者：
Evans, DA;Hebert, LE;Taylor, JO
通讯作者：
Taylor, JO