Chronic neurobehavioral effects of Tokyo subway sarin poisoning in relation to posttraumatic stress disorder.
Chronic neurobehavioral effects of Tokyo subway sarin poisoning in relation to posttraumatic stress disorder.
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东京地铁沙林中毒与创伤后应激障碍相关的慢性神经行为影响。
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
Roberta F. White
中科院分区：
文献类型：
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作者：
K. Yokoyama;Shunichi Araki;Katsuyuki Murata;Mariko Nishikitani;Tetsu Okumura;Shinichi Ishimatsu;N. Takasu;Roberta F. White
对日本东京地铁沙林中毒事件中9名男性和9名女性急性沙林中毒患者的慢性神经行为影响进行了评价。研究人员在中毒发生后6-8个月进行了9项神经行为测试，以及创伤后应激障碍检查表。中毒当天患者血清胆碱酯酶活性（即，1995年3月20日）范围为13 - 131 IU/l（平均值=72.1 IU/l）。协方差分析的结果，其中年龄，教育水平，饮酒量，吸烟状况（协变量）控制在18例沙林病例和18例对照组，数字符号（精神表现）测试的分数显着低于沙林病例组比对照组。尽管如此，沙林病例的一般健康量表、情绪状态简介的疲劳和创伤后应激障碍检查表的得分明显高于对照组。研究人员将创伤后应激障碍添加到协变量中，只有数字符号测试的分数在沙林案例中显着降低。此外，对18例沙林病例进行逐步多元回归分析的结果显示，一般健康状况、情绪状态特征的疲劳（即，疲劳、紧张-焦虑、抑郁和愤怒-敌意）--以及配对联想学习测试--与创伤后应激障碍显著相关。数字符号测试分数的相关性并不显著。急性沙林中毒可能直接造成对精神表现的慢性影响;另一方面，对精神症状（一般健康问卷）和疲劳（情绪状态简介）的影响似乎是由于接触沙林引起的创伤后应激障碍。
Chronic neurobehavioral effects of acute sarin poisoning were evaluated in 9 male and 9 female patients who were exposed to sarin poisoning in the Tokyo subway incident in Japan. The investigators used nine neurobehavioral tests, as well as a posttraumatic stress disorder checklist, 6-8 mo after the poisoning occurred. Serum cholinesterase activity in patients on the day of poisoning (i.e., March 20, 1995) ranged from 13 to 131 IU/l (mean=72.1 IU/l). The results of analysis covariance, in which age, education level, alcohol consumption, and smoking status (covariates) were controlled in 18 sarin cases and in 18 controls, showed that the score on the digit symbol (psychomotor performance) test was significantly lower in the sarin cases than in controls. Nonetheless, the scores for the General Health Questionnaires, fatigue of Profile of Mood States, and posttraumatic stress disorder checklist were significantly higher in the sarin cases than controls. The investigators added posttraumatic stress disorder to the covariates, and only the score on the digit symbol test was significantly lower in sarin cases. In addition, the results of stepwise multiple regression analysis in 18 sarin cases revealed that scores for the General Health Questionnaires, fatigue of Profile of Mood States (i.e., fatigue, tension-anxiety, depression, and anger-hostility)-together with the paired-associate learning test-were associated significantly with posttraumatic stress disorder. The association did not remain significant for the digit symbol test score. Perhaps a chronic effect on psychomotor performance was caused directly by acute sarin poisoning; on the other hand, the effects on psychiatric symptoms (General Health Questionnaire) and fatigue (Profile of Mood States) appeared to result from posttraumatic stress disorder induced by exposure to sarin.
DOI：
10.1176/ajp.152.7.973
发表时间：
1995-07
期刊：
The American journal of psychiatry
影响因子：
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作者：
J. Bremner;P. Randall;T. Scott;R. Bronen;J. Seibyl;S. Southwick;R. Delaney;G. McCarthy;D. Cha
通讯作者：
J. Bremner;P. Randall;T. Scott;R. Bronen;J. Seibyl;S. Southwick;R. Delaney;G. McCarthy;D. Cha
DOI：
10.1176/ajp.152.1.137
发表时间：
1995
期刊：
The American journal of psychiatry
影响因子：
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作者：
R. Yehuda;R. Keefe;Philip D. Harvey;R. Levengood;D. Gerber;J. Geni;L. Siever
通讯作者：
R. Yehuda;R. Keefe;Philip D. Harvey;R. Levengood;D. Gerber;J. Geni;L. Siever