Causal relationship between adiponectin and metabolic traits: a Mendelian randomization study in a multiethnic population.
Causal relationship between adiponectin and metabolic traits: a Mendelian randomization study in a multiethnic population.
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DOI：
10.1371/journal.pone.0066808
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
SHARE-AP Investigators
中科院分区：
文献类型：
--
作者：
Mente A;Meyre D;Lanktree MB;Heydarpour M;Davis AD;Miller R;Gerstein H;Hegele RA;Yusuf S;Anand SS;SHARE Investigators;SHARE-AP Investigators
脂联素是一种仅由脂肪细胞产生的促分泌素，与代谢特征有关，但其在代谢综合征发生中的作用仍不清楚。我们使用观察和遗传流行病学方法在加拿大聚集的多种族人群中研究了血清脂联素水平与代谢特征之间的关联。收集了 SHARE/SHARE-AP 研究的 1,157 名参与者的临床数据和血清脂联素水平。对参与者 ADIPOQ 和 GCKR 基因中的功能性 rs266729 和 rs1260326 SNP 进行基因分型。脂联素水平与HDL胆固醇呈正相关，与体重指数、腰臀比、甘油三酯、空腹血糖、空腹胰岛素、收缩压和舒张压呈负相关（均P<0.002）。 rs266729 小 G 等位基因与较低的脂联素和较高的 HOMA-IR 相关（P = 0.004 和 0.003，分别）。调整脂联素浓度后，rs266729 SNP 和 HOMA-IR 之间的关联不再显着 (P = 0.10)。 rs266729 SNP 与 HOMA-IR 的关联程度超过了其对脂联素水平的影响 (0.15 SD 95% C.I. [0.06, 0.24], P<0.001)。 rs266729 SNP 与种族在脂联素或 HOMA-IR 上没有显着的相互作用。相反，GCKR 中的 SNP rs1260326 与 HOMA-IR 相关（P<0.001），但与脂联素水平无关（P = 0.67）。功能启动子多态性rs266729与不同种族群体中血清脂联素降低和胰岛素抵抗增加的关联可能表明脂联素水平和胰岛素抵抗之间存在因果关系。
Adiponectin, a secretagogue exclusively produced by adipocytes, has been associated with metabolic features, but its role in the development of the metabolic syndrome remains unclear. We investigated the association between serum adiponectin level and metabolic traits, using both observational and genetic epidemiologic approaches in a multiethnic population assembled in Canada. Clinical data and serum adiponectin level were collected in 1,157 participants of the SHARE/SHARE-AP studies. Participants were genotyped for the functional rs266729 and rs1260326 SNPs in ADIPOQ and GCKR genes. Adiponectin level was positively associated with HDL cholesterol and negatively associated with body mass index, waist-to-hip ratio, triglycerides, fasting glucose, fasting insulin, systolic and diastolic pressure (all P<0.002). The rs266729 minor G allele was associated with lower adiponectin and higher HOMA-IR (P = 0.004 and 0.003, respectively). The association between rs266729 SNP and HOMA-IR was no longer significant after adjustment for adiponectin concentration (P = 0.10). The rs266729 SNP was associated with HOMA-IR to an extent that exceeded its effect on adiponectin level (0.15 SD 95% C.I. [0.06, 0.24], P<0.001). There was no significant interaction between rs266729 SNP and ethnicity on adiponectin or HOMA-IR. In contrast, the SNP rs1260326 in GCKR was associated with HOMA-IR (P<0.001), but not with adiponectin level (P = 0.67). The association of the functional promoter polymorphism rs266729 with lower serum adiponectin and increased insulin resistance in diverse ethnic groups may suggest a causal relationship between adiponectin level and insulin resistance.
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影响因子：
5.3
作者：
Heid, Iris M.;Henneman, Peter;Hicks, Andrew;Coassin, Stefan;Winkler, Thomas;Aulchenko, Yurii S.;Fuchsberger, Christian;Song, Kijoung;Hivert, Marie-France;Waterworth, Dawn M.;Timpson, Nicholas J.;Richards, J. Brent;Perry, John R. B.;Tanaka, Toshiko;Amin, Najaf;Kollerits, Barbara;Pichler, Irene;Oostra, Ben A.;Thorand, Barbara;Frants, Rune R.;Illig, Thomas;Dupuis, Josee;Glaser, Beate;Spector, Tim;Guralnik, Jack;Egan, Josephine M.;Florez, Jose C.;Evans, David M.;Soranzo, Nicole;Bandinelli, Stefania;Carlson, Olga D.;Frayling, Timothy M.;Burling, Keith;Smith, George Davey;Mooser, Vincent;Ferrucci, Luigi;Meigs, James B.;Vollenweider, Peter;van Dijk, Ko Willems;Pramstaller, Peter;Kronenberg, Florian;van Duijn, Cornelia M.
通讯作者：
van Duijn, Cornelia M.
影响因子：
8.3
作者：
Chow, Wing-Sun;Cheung, Bernard M. Y.;Lam, Karen S. L.
通讯作者：
Lam, Karen S. L.
影响因子：
9.8
作者：
Jee, Sun Ha;Sull, Jae Woong;Beaty, Terri H.
通讯作者：
Beaty, Terri H.
影响因子：
4.8
作者：
Combs, TP;Pajvani, UB;Scherer, PE
通讯作者：
Scherer, PE
DOI：
10.1016/j.metabol.2008.09.002
发表时间：
2009-01
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
Goropashnaya AV;Herron J;Sexton M;Havel PJ;Stanhope KL;Plaetke R;Mohatt GV;Boyer BB
通讯作者：
Boyer BB