Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study.
Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study.
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DOI：
10.1016/j.metabol.2008.09.002
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Boyer BB
中科院分区：
文献类型：
--
作者：
Goropashnaya AV;Herron J;Sexton M;Havel PJ;Stanhope KL;Plaetke R;Mohatt GV;Boyer BB
脂联素是一种由脂肪组织分泌的蛋白质，具有抗动脉粥样硬化、抗炎和胰岛素增敏作用。我们在阿拉斯加西南部的316名男性和353名女性Yup'ik爱斯基摩人中研究了血浆脂联素与肥胖、胰岛素抵抗、血脂、血糖、瘦素和人体测量的关系。在男性和女性中，脂联素浓度与BMI、体脂百分比、皮肤褶皱总数、腰围、甘油三酯、胰岛素抵抗（HOMA-IR）、空腹胰岛素和瘦素呈负相关，女性中也与血糖呈负相关。女性脂联素浓度与高密度脂蛋白胆固醇（HDL-C）浓度呈正相关，也与低密度脂蛋白胆固醇呈正相关。胰岛素敏感个体（HOMA-IR < 3.52，n = 442）的血浆脂联素浓度高于胰岛素抵抗个体（HOMA-IR ≥ 3.52，n = 224）：11.02 ± 0.27 μg/mL vs. 8.26 ± 0.32 μg/mL，P <0.001。脂联素浓度在冠心病低风险组和高风险组之间没有差异。在性别、年龄和BMI匹配的爱斯基摩人和高加索人中，血浆脂联素水平没有差异。总之，循环脂联素浓度与Yup'ik男性的皮肤褶皱总和和Yup'ik女性的HDL-C水平、皮肤褶皱总和、腰围、胰岛素和甘油三酯浓度最密切相关。
Adiponectin, a protein, secreted by adipose tissue has anti-atherogenic, anti-inflammatory, and insulin-sensitizing actions. We examined the relationship between plasma adiponectin and adiposity, insulin resistance, plasma lipids, glucose, leptin and anthropometric measurements in adult 316 men and 353 women Yup’ik Eskimos in Southwest Alaska. Adiponectin concentration was negatively associated with BMI, percent of body fat, sum of skin folds, waist circumference, triglycerides, insulin resistance (HOMA-IR), fasting insulin, and leptin in both men and women, and also with glucose in women. Adiponectin concentration correlated positively with high density lipoprotein cholesterol (HDL-C) concentration, and also with low density lipoprotein cholesterol in women. Insulin sensitive individuals (HOMA-IR < 3.52, n = 442) had higher plasma adiponectin concentrations than more insulin resistant individuals (HOMA-IR ≥ 3.52, n = 224): 11.02 ± 0.27 μg/mL vs. 8.26 ± 0.32 μg/mL, P <.001. Adiponectin concentrations did not differ between groups of participants with low and high level of risk for developing coronary heart disease. No difference in plasma adiponectin levels was found among Yup’ik Eskimos and Caucasians matched for sex, age and BMI. In conclusion, circulating adiponectin concentrations were most strongly associated with sum of skin folds in Yup’ik men and with HDL-C levels, sum of skin folds, waist circumference, insulin and triglycerides concentrations in Yup’ik women.
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