Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly.
Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly.
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DOI：
10.1146/annurev-neuro-100322-112249
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发表时间：
2023-07-10
影响因子：
13.9
通讯作者：
中科院分区：
文献类型：
--
作者：
本文综述了昼夜节律计时与星形胶质细胞调节脑功能之间的关系。虽然星形胶质细胞在许多时间域调节神经元活动，但它们的细胞自主生物钟在控制大脑功能的长期振荡方面发挥着特殊作用：维持睡眠状态以及睡眠和觉醒的昼夜节律顺序。这在中央昼夜节律起搏器（视交叉上核）中最为明显，星形胶质细胞的分子钟足以驱动神经元活动和行为的每日周期。在阿尔茨海默病中，睡眠障碍伴随认知能力下降。在该疾病的小鼠模型中，昼夜节律紊乱加速了星形胶质细胞的激活和其他脑病理，这表明星形胶质细胞的日常功能保护了神经元的稳态。在脑癌中，早晨治疗与延长生存期有关，胶质瘤在基因表达和药物敏感性方面具有每日节律。因此，昼夜节律时间对于阐明健康和疾病中的相互星形胶质细胞-神经元相互作用迅速变得至关重要。
This review explores the interface between circadian timekeeping and the regulation of brain function by astrocytes. Although astrocytes regulate neuronal activity across many time domains, their cell-autonomous circadian clocks exert a particular role in controlling longer-term oscillations of brain function: the maintenance of sleep states and the circadian ordering of sleep and wakefulness. This is most evident in the central circadian pacemaker, the suprachiasmatic nucleus, where the molecular clock of astrocytes suffices to drive daily cycles of neuronal activity and behavior. In Alzheimer’s disease, sleep impairments accompany cognitive decline. In mouse models of the disease, circadian disturbances accelerate astroglial activation and other brain pathologies, suggesting that daily functions in astrocytes protect neuronal homeostasis. In brain cancer, treatment in the morning has been associated with prolonged survival, and gliomas have daily rhythms in gene expression and drug sensitivity. Thus, circadian time is fast becoming critical to elucidating reciprocal astrocytic-neuronal interactions in health and disease.
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影响因子：
16.6
作者：
Barca-Mayo O;Pons-Espinal M;Follert P;Armirotti A;Berdondini L;De Pietri Tonelli D
通讯作者：
De Pietri Tonelli D
昼夜节律对衰老和寿命的重要性。
影响因子：
16.6
作者：
Acosta-Rodríguez VA;Rijo-Ferreira F;Green CB;Takahashi JS
通讯作者：
Takahashi JS
影响因子：
3.2
作者：
Aziz, N. A.;Pijl, H.;Roos, R. A. C.
通讯作者：
Roos, R. A. C.
影响因子：
8
作者：
Bagci, T.;Wu, J. K.;Jay, D. G.
通讯作者：
Jay, D. G.
影响因子：
9.2
作者：
Akhtar, RA;Reddy, AB;Kyriacou, CP
通讯作者：
Kyriacou, CP