Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor.
Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor.
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DOI：
10.1016/j.neuroscience.2012.10.073
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发表时间：
2013-06-03
期刊：
影响因子：
3.3
通讯作者：
Handa, R. J.
中科院分区：
文献类型：
--
作者：
Carbone, D. L.;Handa, R. J.
神经营养因子，脑源性神经营养因子（BDNF），被认为是调节中枢神经系统个体发育、体内平衡和成人神经可塑性的关键成分。BDNF在中枢神经系统发育和功能中的重要性已被大量动物研究报告充分证明，这些研究将异常BDNF信号传导与代谢紊乱、焦虑或抑郁样行为联系起来。尽管BDNF在中枢神经系统生理学的几乎所有方面都发挥着不同的作用，但BDNF表达的调控以及我们对这种神经营养因子相关的信号传导机制的理解仍然不完整。然而，性激素之间的联系，如雌二醇和睾酮，以及内源性和合成糖皮质激素，已经成为BDNF表达和功能的重要介质。这种调节的例子包括脑区域特异性诱导Bdnf mRNA响应雌二醇。其他研究也证实雌二醇调节高亲和力BDNF受体TrkB的表达，从而暗示性类固醇不仅参与BDNF表达的调节，还参与与之相关的信号传导机制。除了性腺类固醇，进一步的证据还表明BDNF与糖皮质激素之间的功能相互作用，例如在调节促肾上腺皮质激素释放激素和其他重要神经肽方面。在这篇综述中，我们概述了一些性激素或应激激素在中枢神经系统BDNF表达和信号传导调控中的作用
The neurotrophin, brain-derived neurotrophic factor (BDNF), is recognized as a key component in the regulation of central nervous system ontogeny, homeostasis and adult neuroplasticity. The importance of BDNF in central nervous system development and function is well documented by numerous reports from animal studies linking abnormal BDNF signaling to metabolic disturbances and anxiety or depressive-like behavior. Despite the diverse roles for BDNF in nearly all aspects of central nervous system physiology, the regulation of BDNF expression, as well as our understanding of the signaling mechanisms associated with this neurotrophin, remains incomplete. However, links between sex hormones such as estradiol and testosterone, as well as endogenous and synthetic glucocorticoids, have emerged as important mediators of BDNF expression and function. Examples of such regulation include brain region-specific induction of Bdnf mRNA in response to estradiol. Additional studies have also documented regulation of the expression of the high-affinity BDNF receptor TrkB by estradiol, thus implicating sex steroids not only in the regulation of BDNF expression, but on mechanisms of signaling associated with it. In addition to gonadal steroids, further evidence also suggests functional interaction between BDNF and glucocorticoids, such as in the regulation of corticotrophin-releasing hormone and other important neuropeptides. In this review, we provide an overview of the roles played by selected sex or stress hormones in the regulation of BDNF expression and signaling in the central nervous system
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