A distinct parabrachial-to-lateral hypothalamus circuit for motivational suppression of feeding by nociception.
A distinct parabrachial-to-lateral hypothalamus circuit for motivational suppression of feeding by nociception.
复制标题
DOI：
10.1126/sciadv.abe4323
复制
发表时间：
2021-05
期刊：
影响因子：
13.6
通讯作者：
Fu Y
中科院分区：
文献类型：
--
作者：
Phua SC;Tan YL;Kok AMY;Senol E;Chiam CJH;Lee CY;Peng Y;Lim ATJ;Mohammad H;Lim JX;Fu Y
用于解决进食和急性疼痛之间的动机冲突的特定神经回路。进食的动机不仅受到营养的影响，而且还受到包括疼痛在内的外部刺激的影响。小鼠下丘脑作为摄食调节中心，如何整合伤害性信息来调节摄食尚不清楚。在关键的伤害性感受传递中枢臂旁核(PBN)内，我们发现投射到下丘脑外侧核(LHPBN)的神经元是伤害性的，但与编码危险的中央杏仁核(CeAPBN)神经元不同。LHPBN的激活通过限制进食频率强烈地抑制了摄食，并降低了为食物奖励而工作的动机。改进的接近-回避范式显示，抑制LHPBN，而不是CeAPBN，是获得食物的持续动机。LHPBN神经元对摄食的影响可通过抑制下游的LHVGluT2神经元而逆转。因此，与恐惧和逃避反应的回路不同，LHPBN神经元将伤害性信号传导到LHVGluT2神经元，以抑制摄食的动机动力。我们的研究为理解外部竞争刺激对摄食的调控提供了一个新的视角。
A specific neural circuit for resolving the motivational conflict between feeding and acute pain. The motivation to eat is not only shaped by nutrition but also competed by external stimuli including pain. How the mouse hypothalamus, the feeding regulation center, integrates nociceptive inputs to modulate feeding is unclear. Within the key nociception relay center parabrachial nucleus (PBN), we demonstrated that neurons projecting to the lateral hypothalamus (LHPBN) are nociceptive yet distinct from danger-encoding central amygdala–projecting (CeAPBN) neurons. Activation of LHPBN strongly suppressed feeding by limiting eating frequency and also reduced motivation to work for food reward. Refined approach-avoidance paradigm revealed that suppression of LHPBN, but not CeAPBN, sustained motivation to obtain food. The effect of LHPBN neurons on feeding was reversed by suppressing downstream LHVGluT2 neurons. Thus, distinct from a circuit for fear and escape responses, LHPBN neurons channel nociceptive signals to LHVGluT2 neurons to suppress motivational drive for feeding. Our study provides a new perspective in understanding feeding regulation by external competing stimuli.
登录
查看更多内容
影响因子：
16.2
作者：
Burnett CJ;Li C;Webber E;Tsaousidou E;Xue SY;Brüning JC;Krashes MJ
通讯作者：
Krashes MJ
影响因子：
5.3
作者：
Carter, Matthew E.;Han, Sung;Palmiter, Richard D.
通讯作者：
Palmiter, Richard D.
影响因子：
29
作者：
Campos CA;Bowen AJ;Schwartz MW;Palmiter RD
通讯作者：
Palmiter RD
影响因子：
64.8
作者：
Kim, Dong-Yoon;Heo, Gyuryang;Kim, Sung-Yon
通讯作者：
Kim, Sung-Yon
影响因子：
64.5
作者：
Han S;Soleiman MT;Soden ME;Zweifel LS;Palmiter RD
通讯作者：
Palmiter RD