Hunger-Driven Motivational State Competition.
Hunger-Driven Motivational State Competition.
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DOI：
10.1016/j.neuron.2016.08.032
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发表时间：
2016-10-05
期刊：
影响因子：
16.2
通讯作者：
Krashes MJ
中科院分区：
文献类型：
--
作者：
Burnett CJ;Li C;Webber E;Tsaousidou E;Xue SY;Brüning JC;Krashes MJ
行为选择在动物界无处不在，是目标导向行为的核心。下丘脑Agti相关肽(AgRP)神经元是食欲的重要调节因子。众所周知，在多种感官刺激的轰炸下，饥饿的动物会在卡路里需求的时候改变自己的行为，迅速适应不断变化的环境。利用ARCAgRP神经元作为切入点，我们分析了饥饿与竞争驱动状态相关的等级位置。通过一系列行为分析，我们发现，饥饿显著增强了其抑制相互竞争的动机系统的能力，如口渴、焦虑相关行为、天生恐惧和社交互动，通常只有在食物可获得的情况下才会如此。此外，对ARCAgRP活性的实时监测显示，除了食物呈现外，对同种研究的时间锁定反应，进一步证明即使在ARCAgRP神经元水平上，选择也是非常灵活的计算，整合了内部状态、外部因素和预期产量。
Behavioral choice is ubiquitous in the animal kingdom and is central to goal-oriented behavior. Hypothalamic Agouti-related peptide (AgRP) neurons are critical regulators of appetite. Hungry animals, bombarded by multiple sensory stimuli, are known to modify their behavior during times of caloric need, rapidly adapting to a consistently changing environment. Utilizing ARCAgRP neurons as an entry point, we analyzed the hierarchical position of hunger related to rival drive states. Employing a battery of behavioral assays we found that hunger significantly increases its capacity to suppress competing motivational systems such as thirst, anxiety-related behavior, innate fear and social interactions often only when food is accessible. Furthermore, real-time monitoring of ARCAgRP activity revealed time-locked responses to conspecific investigation in addition to food presentation, further establishing that even at the level of ARCAgRP neurons choices are remarkably flexible computations integrating internal state, external factors and anticipated yield.
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影响因子：
3
作者：
Falkner AL;Lin D
通讯作者：
Lin D
DOI：
10.1002/bies.201500167
发表时间：
2016-04
期刊：
BioEssays : news and reviews in molecular, cellular and developmental biology
影响因子：
--
作者：
Chen Y;Knight ZA
通讯作者：
Knight ZA
影响因子：
64.5
作者：
Dietrich MO;Zimmer MR;Bober J;Horvath TL
通讯作者：
Horvath TL
影响因子：
7.7
作者：
Henry FE;Sugino K;Tozer A;Branco T;Sternson SM
通讯作者：
Sternson SM
影响因子：
64.8
作者：
Cui, Guohong;Jun, Sang Beom;Jin, Xin;Pham, Michael D.;Vogel, Steven S.;Lovinger, David M.;Costa, Rui M.
通讯作者：
Costa, Rui M.