The dual role of N6-methyladenosine modification of RNAs is involved in human cancers.
The dual role of N6-methyladenosine modification of RNAs is involved in human cancers.
复制标题
RNA 的 N6-甲基腺苷修饰的双重作用与人类癌症有关。
DOI：
10.1111/jcmm.13804
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发表时间：
2018-10
影响因子：
5.3
通讯作者：
Xie L
中科院分区：
文献类型：
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作者：
He L;Li J;Wang X;Ying Y;Xie H;Yan H;Zheng X;Xie L
As the most abundant and reversible RNA modification in eukaryotic cells, m6A triggers a new layer of epi‐transcription. M6A modification occurs through a methylation process modified by “writers” complexes, reversed by “erasers”, and exerts its role depending on various “readers”. Emerging evidence shows that there is a strong association between m6A and human diseases, especially cancers. Herein, we review bi‐aspects of m6A in regulating cancers mediated by the m6A‐associated proteins, which exert vital and specific roles in the development of various cancers. Generally, the m6A modification performs promotion or inhibition functions (dual role) in tumorigenesis and progression of various cancers, which suggests a new concept in cancer regulations. In addition, m6A‐targeted therapies including competitive antagonists of m6A‐associated proteins may provide a new tumour intervention in the future.
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影响因子：
23.9
作者：
Aguilo F;Zhang F;Sancho A;Fidalgo M;Di Cecilia S;Vashisht A;Lee DF;Chen CH;Rengasamy M;Andino B;Jahouh F;Roman A;Krig SR;Wang R;Zhang W;Wohlschlegel JA;Wang J;Walsh MJ
通讯作者：
Walsh MJ
影响因子：
16.6
作者：
Chen, Kai;Lu, Zhike;Wang, Xiao;Fu, Ye;Luo, Guan-Zheng;Liu, Nian;Han, Dali;Dominissini, Dan;Dai, Qing;Pan, Tao;He, Chuan
通讯作者：
He, Chuan
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.
影响因子：
6.4
作者：
Guruswamy, Suresh;Swamy, Malisetty V.;Rao, Chinthalapally V.
通讯作者：
Rao, Chinthalapally V.
DOI：
10.1016/j.gpb.2017.03.002
发表时间：
2017-06
期刊：
Genomics, proteomics & bioinformatics
影响因子：
--
作者：
Batista PJ
通讯作者：
Batista PJ