Pseudouridine as a novel biomarker in prostate cancer.
Pseudouridine as a novel biomarker in prostate cancer.
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DOI：
10.1016/j.urolonc.2020.06.026
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Tewari AK
中科院分区：
文献类型：
--
作者：
Stockert JA;Weil R;Yadav KK;Kyprianou N;Tewari AK
表观转录组分析最近对癌细胞生物基质中的修饰核苷进行了分析，有助于阐明它们在癌症中的功能作用，并重新激发了人们对探索它们作为癌症发生和进展的潜在标志物的兴趣。假尿苷是最知名、最丰富的 RNA 核苷酸修饰之一，是尿苷的 C5-糖苷异构体，其独特的理化性质使其能够执行许多基本功能。假尿苷在功能上 (a) 通过增强 RNA 堆积赋予局部 RNA 结构刚性，与邻近核苷产生协同作用，总体上有助于 RNA 稳定 (b) 细化 tRNA 的结构，从而影响其解码活性 (c) 促进翻译过程中解码和校对的准确性以及肽键形成的效率，从而共同提高蛋白质生物合成的保真度，以及 (e) 动态调节 mRNA 编码和翻译。假尿苷的生化合成是通过假尿苷合酶进行的。在这篇综述中，我们讨论了支持假尿苷水平升高与人类前列腺癌的发病率和进展之间存在关联的证据，以及这种修饰核苷酸作为前列腺癌进展为晚期疾病的新型生物标志物的价值的转化意义。
Epitranscriptomic analysis has recently led to the profiling of modified nucleosides in cancer cell biological matrices, helping to elucidate their functional roles in cancer and reigniting interest in exploring their use as potential markers of cancer development and progression. Pseudouridine, one of the most well-known and the most abundant of the RNA nucleotide modifications, is the C5-glycoside isomer of uridine and its distinctive physiochemical properties allows it to perform many essential functions. Pseudouridine functionally (a) confers rigidity to local RNA structure by enhancing RNA stacking, engaging in a cooperative effect on neighboring nucleosides that overall contributes to RNA stabilization (b) refines the structure of tRNAs, which influences their decoding activity (c) facilitates the accuracy of decoding and proofreading during translation and efficiency of peptide bond formation, thus collectively improving the fidelity of protein biosynthesis and (e) dynamically regulates mRNA coding and translation. Biochemical synthesis of pseudouridine is carried out by pseudouridine synthases. In this review we discuss the evidence supporting an association between elevated pseudouridine levels with the incidence and progression of human prostate cancer and the translational significance of the value of this modified nucleotide as a novel biomarker in prostate cancer progression to advanced disease.
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DOI：
10.6004/jnccn.2015.0009
发表时间：
2015-01-01
影响因子：
13.4
作者：
Aizer, Ayal A.;Gu, Xiangmei;Nguyen, Paul L.
通讯作者：
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影响因子：
4.5
作者：
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作者：
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影响因子：
5
作者：
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通讯作者：
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影响因子：
4.3
作者：
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