Recent Advances in Identification of RNA Modifications.

Recent Advances in Identification of RNA Modifications.
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DOI:
10.3390/ncrna3010001
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发表时间:
2016-12-28
期刊:
影响因子:
4.3
通讯作者:
Lin H
Lin H
中科院分区:
其他
文献类型:
--
作者:
Chen W;Lin H

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RNA修饰涉及广泛的生物和生理过程。为了揭示RNA修饰的功能,准确地预测它们的位置是重要的。虽然已经提出了高通量的实验技术,但它们的成本效益不高。作为对实验的很好补充,近年来提出了许多计算方法来预测RNA修饰位点。在这篇综述中,我们将总结现有的针对RNA修饰位点预测的计算方法。我们还将讨论在开发可靠的方法来预测RNA修饰位点方面的挑战和未来的前景。
RNA modifications are involved in a broad spectrum of biological and physiological processes. To reveal the functions of RNA modifications, it is important to accurately predict their positions. Although high-throughput experimental techniques have been proposed, they are cost-ineffective. As good complements of experiments, many computational methods have been proposed to predict RNA modification sites in recent years. In this review, we will summarize the existing computational approaches directed at predicting RNA modification sites. We will also discuss the challenges and future perspectives in developing reliable methods for predicting RNA modification sites.
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