Treatments of traumatic neuropathic pain: a systematic review.
Treatments of traumatic neuropathic pain: a systematic review.
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创伤性神经病理性疼痛的治疗：系统评价
DOI：
10.18632/oncotarget.16917
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发表时间：
2017-08-22
期刊：
影响因子：
--
通讯作者：
Yan H
中科院分区：
文献类型：
--
作者：
Yao C;Zhou X;Zhao B;Sun C;Poonit K;Yan H
创伤性神经瘤引起的创伤性神经病理性疼痛长期以来一直困扰着医生和患者，创伤性神经病理性疼痛的发生机制受到研究者的广泛讨论，其治疗具有挑战性。疼痛性神经瘤的临床治疗尚不清楚。这一领域的专家提出了许多治疗方法。然而，目前还没有一个统一的公认标准。不同形式的治疗已经在动物和人类中进行了测试，但药物治疗（抗抑郁药，抗癫痫药）仍然是创伤性神经性疼痛管理的基础。对于难治性病例，将神经残端移位到肌肉、静脉或骨中被视为传统的外科手术，其提供了一定程度的疗效。近年来出现了一些新的外科技术，如导管引导神经帽术、电刺激和自体脂肪移植等，大大丰富了创伤性神经病理性疼痛的治疗手段。几种治疗方法在缓解疼痛和预防神经瘤形成方面显示出优于其他方法的优势，因此很难选择一种单一的治疗方法作为参考。创伤性神经病理性疼痛的有效、规范化治疗将为研究者和临床工作者提供更好的选择。本文就创伤性神经病理性疼痛的治疗现状进行综述，并探讨其治疗策略。本研究旨在为创伤性神经病理性疼痛的治疗提供一种有效的方法。
Traumatic neuropathic pain caused by traumatic neuroma has long been bothering both doctors and patients, the mechanisms of traumatic neuropathic pain are widely discussed by researchers and the treatment is challenging. Clinical treatment of painful neuroma is unclear. Numerous treatment modalities have been introduced by experts in this field. However, there is still no single standard recognized treatment. Different forms of treatments have been tested in animals and humans, but pharmacotherapies (antidepressants, antiepileptics) remain the basis of traumatic neuropathic pain management. For intractable cases, nerve stump transpositions into a muscle, vein or bone are seen as traditional surgical procedures which provide a certain degree of efficacy. Novel surgical techniques have emerged in recent years, such as tube guided nerve capping, electrical stimulation and adipose autograft have substantially enriched the abundance of the treatment for traumatic neuropathic pain. Several treatments show advantages over the others in terms of pain relief and prevention of neuroma formation, making it difficult to pick out a single modality as the reference. An effective and standardized treatment for traumatic neuropathic pain would provide better choice for researchers and clinical workers. In this review, we summarized current knowledge on the treatment of traumatic neuropathic pain, and found a therapeutic strategy for this intractable pain. We tried to provide a useful guideline for choosing the right modality in management of traumatic neuropathic pain.
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DOI：
10.4103/0975-5950.102175
发表时间：
2012-01
期刊：
National journal of maxillofacial surgery
影响因子：
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作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1302/0301-620x.91b6.22145
发表时间：
2009-06-01
影响因子：
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作者：
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