Recent advances in the use of serological bone formation markers to monitor callus development and fracture healing.
Recent advances in the use of serological bone formation markers to monitor callus development and fracture healing.
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DOI：
10.1615/critreveukargeneexpr.v20.i2.20
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发表时间：
2010
影响因子：
1.6
通讯作者：
Jones CB
中科院分区：
文献类型：
--
作者：
Coulibaly MO;Sietsema DL;Burgers TA;Mason J;Williams BO;Jones CB
骨性骨折无法愈合或骨不连的现象很常见。然而，目前的诊断措施缺乏及早、可靠地检测此类事件的能力。放射成像和临床检查的分析相结合，仍然是诊断的金标准；然而，这些方法对于早期检测来说并不可靠。从患者和治疗的角度来看，骨不连的延迟诊断代价高昂。为此，人们不断努力确定骨代谢标志物作为监测骨愈合的诊断或预后工具。迄今为止，有关大多数骨代谢标志物动力学与骨不连之间相关性的证据非常有限。为了对骨代谢的生物学途径的作用进行分类并了解骨质疏松症发展中的骨状况，我们对骨重塑、骨折愈合及其失败的分子基础的认识取得了进展。 I 型原胶原氨基末端前肽已被证明是骨质疏松症治疗中可靠的骨形成标志物，并且最近描述了其在骨折愈合过程中的动力学。在本文中，我们建议 I 型前胶原氨基末端前肽为早期检测骨不连提供了良好的机会。我们还回顾了血清 PINP 以及其他标志物作为骨折愈合指征的作用和潜力。
The failure of an osseous fracture to heal, or the development of a nonunion, is common; however, current diagnostic measures lack the capability of early and reliable detection of such events. Analyses of radiographic imaging and clinical examination, in combination, remain the gold standard for diagnosis; however, these methods are not reliable for early detection. Delayed diagnosis of a nonunion is costly from both the patient and treatment standpoints. In response, repeated efforts have been made to identify bone metabolic markers as diagnostic or prognostic tools for monitoring bone healing. Thus far, the evidence regarding a correlation between the kinetics of most bone metabolic markers and nonunion is very limited. With the aim of classifying the role of biological pathways of bone metabolism and of understanding bone conditions in the development of osteoporosis, advances have been made in our knowledge of the molecular basis of bone remodeling, fracture healing, and its failure. Procollagen type I amino-terminal propeptide has been shown to be a reliable bone formation marker in osteoporosis therapy and its kinetics during fracture healing has been recently described. In this article, we suggest that procollagen type I amino-terminal propeptide presents a good opportunity for early detection of nonunion. We also review the role and potential of serum PINP, as well as other markers, as indications of fracture healing.
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DOI：
10.1097/ta.0b013e3181469840
发表时间：
2008-06-01
影响因子：
--
作者：
Court-Brown, Charles M.;McQueen, Margaret M.
通讯作者：
McQueen, Margaret M.
影响因子：
3.3
作者：
Christensen, Britt;Dyrberg, Eva;Langberg, Henning
通讯作者：
Langberg, Henning
影响因子：
4.1
作者：
Alvarez, L;Guañabens, N;Ballesta, AM
通讯作者：
Ballesta, AM
影响因子：
1.2
作者：
Chiba, S;Okada, K;Neer, RM
通讯作者：
Neer, RM
影响因子：
6.2
作者：
Bauer, DC;Garnero, P;Black, DM
通讯作者：
Black, DM