Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches.
Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches.
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DOI：
10.4103/1319-3767.96445
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Ahmad R
中科院分区：
文献类型：
--
作者：
Ahmad A;Ahmad R
肝纤维化（HF）是一种进行性疾病，具有严重的临床并发症，由坚韧的纤维瘢痕组织异常增生和积聚引起。由于肝功能的最终衰竭，这种对胶原纤维的蔑视是致命的。多种细胞类型的参与、相互联系的细胞事件以及大量的中介分子使得纤维化过程极其复杂和动态。然而，随着对纤维化的潜在细胞和分子机制的更好认识，心衰不能治愈的假设正在逐渐改变。最近的研究结果强调了许多合成化合物以及植物衍生物在停止甚至逆转肝脏转化为纤维化组织的过程方面的治疗潜力。预计未来的投入将提供一个概念性框架，以制定更具体的策略，促进风险因素的评估，早期诊断生物标志物的候选名单，并最终指导有效治疗方案的开发。
Hepatic fibrosis (HF) is a progressive condition with serious clinical complications arising from abnormal proliferation and amassing of tough fibrous scar tissue. This defiance of collagen fibers becomes fatal due to ultimate failure of liver functions. Participation of various cell types, interlinked cellular events, and large number of mediator molecules make the fibrotic process enormously complex and dynamic. However, with better appreciation of underlying cellular and molecular mechanisms of fibrosis, the assumption that HF cannot be cured is gradually changing. Recent findings have underlined the therapeutic potential of a number of synthetic compounds as well as plant derivatives for cessation or even the reversal of the processes that transforms the liver into fibrotic tissue. It is expected that future inputs will provide a conceptual framework to develop more specific strategies that would facilitate the assessment of risk factors, shortlist early diagnosis biomarkers, and eventually guide development of effective therapeutic alternatives.
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