Two Genomic Loci Control Three Eye Colors in the Domestic Pigeon (Columba livia).
Two Genomic Loci Control Three Eye Colors in the Domestic Pigeon (Columba livia).
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DOI：
10.1093/molbev/msab260
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发表时间：
2021-12-09
影响因子：
10.7
通讯作者：
Shapiro MD
中科院分区：
文献类型：
--
作者：
Maclary ET;Phillips B;Wauer R;Boer EF;Bruders R;Gilvarry T;Holt C;Yandell M;Shapiro MD
眼睛的虹膜在脊椎动物物种中显示出惊人的颜色变化，并且可能在隐藏和交流中发挥重要作用。家鸽（Columba livia）有三种常见的虹膜颜色，橙子，珍珠色（白色）和公牛色（深棕色），分离在一个单一的物种，从而提供了一个独特的机会，以确定虹膜颜色的遗传基础。我们在实验室杂交中使用比较基因组学和遗传作图来确定控制家鸽虹膜颜色变化的两个候选基因。我们确定了溶质载体SLC2A11B中的无义突变，该突变在所有珍珠眼颜色的鸽子中共享，并且与牛眼颜色相关的基因座包括EDNRB 2，EDNRB 2是一种参与神经嵴迁移和色素发育的基因。然而，牛眼很可能是由鸽子品种中等位基因的异质集合控制的。我们还发现，EDNRB 2区域与区域化的羽毛脱色（花斑）。我们的研究确定了眼睛颜色变化的两个候选基因，并建立了虹膜和羽毛颜色之间的遗传联系，这两个特征在鸟类和其他脊椎动物的进化中差异很大。
The iris of the eye shows striking color variation across vertebrate species, and may play important roles in crypsis and communication. The domestic pigeon (Columba livia) has three common iris colors, orange, pearl (white), and bull (dark brown), segregating in a single species, thereby providing a unique opportunity to identify the genetic basis of iris coloration. We used comparative genomics and genetic mapping in laboratory crosses to identify two candidate genes that control variation in iris color in domestic pigeons. We identified a nonsense mutation in the solute carrier SLC2A11B that is shared among all pigeons with pearl eye color, and a locus associated with bull eye color that includes EDNRB2, a gene involved in neural crest migration and pigment development. However, bull eye is likely controlled by a heterogeneous collection of alleles across pigeon breeds. We also found that the EDNRB2 region is associated with regionalized plumage depigmentation (piebalding). Our study identifies two candidate genes for eye colors variation, and establishes a genetic link between iris and plumage color, two traits that vary widely in the evolution of birds and other vertebrates.
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影响因子：
3.3
作者：
Braasch I;Brunet F;Volff JN;Schartl M
通讯作者：
Schartl M
影响因子：
9.2
作者：
Domyan, Eric T.;Guernsey, Michael W.;Kronenberg, Zev;Krishnan, Shreyas;Boissy, Raymond E.;Vickrey, Anna I.;Rodgers, Clifford;Cassidy, Pamela;Leachman, Sancy A.;Fondon, John W., III;Yandell, Mark;Shapiro, Michael D.
通讯作者：
Shapiro, Michael D.
影响因子：
4.6
作者：
Harris, Melissa L.;Hall, Ronelle;Erickson, Carol A.
通讯作者：
Erickson, Carol A.
影响因子：
4.3
作者：
Edwards, Melissa;Cha, David;Parra, Esteban J.
通讯作者：
Parra, Esteban J.
影响因子：
4.5
作者：
Bruders, Rebecca;Van Hollebeke, Hannah;Shapiro, Michael D.
通讯作者：
Shapiro, Michael D.