Dysfunctional T cell metabolism in the tumor microenvironment.
Dysfunctional T cell metabolism in the tumor microenvironment.
复制标题
肿瘤微环境中功能失调的T细胞代谢。
DOI：
10.1016/j.cytogfr.2017.04.003
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发表时间：
2017-06
影响因子：
13
通讯作者：
Rathmell JC
中科院分区：
文献类型：
--
作者：
Beckermann KE;Dudzinski SO;Rathmell JC
Metabolic and signaling pathways are integrated to determine T cell fate and function. As stimulated T cells gain distinct effector functions, specific metabolic programs and demands are also adopted. These changes are essential for T cell effector function, and alterations or dysregulation of metabolic pathways can modulate T cell function. One physiological setting that impacts T cell metabolism is the tumor microenvironment. The metabolism of cancer cells themselves can limit nutrients and accumulate waste products. In addition to the expression of inhibitory ligands that directly modify T cell physiology, T cell metabolism may be strongly inhibited in the tumor microenvironment. This suppression of T cell metabolism may inhibit effector T cell activity while promoting suppressive regulatory T cells, and act as a barrier to effective immunotherapies. A thorough understanding of the effect of the tumor microenvironment on the immune system will support the continued improvement of immune based therapies for cancer patients.
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影响因子：
64.5
作者：
Chang CH;Curtis JD;Maggi LB Jr;Faubert B;Villarino AV;O'Sullivan D;Huang SC;van der Windt GJ;Blagih J;Qiu J;Weber JD;Pearce EJ;Jones RG;Pearce EL
通讯作者：
Pearce EL
影响因子：
3.8
作者：
Garama, Daniel J.;White, Christine L.;Gough, Daniel J.
通讯作者：
Gough, Daniel J.
DOI：
10.1073/pnas.1620433114
发表时间：
2017-01-31
影响因子：
11.1
作者：
Chamoto, Kenji;Chowdhury, Partha S.;Honjo, Tasuku
通讯作者：
Honjo, Tasuku
影响因子：
11.5
作者：
Brandacher, G;Perathoner, A;Amberger, A
通讯作者：
Amberger, A
细胞外嘌呤，嘌呤能受体和肿瘤生长。
影响因子：
8
作者：
Di Virgilio F;Adinolfi E
通讯作者：
Adinolfi E