Sialomucins and carcinoembryonic antigen in the evolution of colorectal cancer
Sialomucins and carcinoembryonic antigen in the evolution of colorectal cancer
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唾液酸粘蛋白和癌胚抗原在结直肠癌进化中的作用
DOI：
10.1111/j.1365-2559.1984.tb02398.x
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发表时间：
1984
期刊：
影响因子：
6.4
通讯作者：
M. Ormerod
中科院分区：
文献类型：
--
作者：
P. Greaves;M. Filipe;S. Abbas;M. Ormerod
我们探索了同时研究唾液粘蛋白含量和癌胚抗原（CEA）表达在腺瘤早期恶性肿瘤鉴定中的优点。通过组织化学和免疫细胞化学技术对 113 例结直肠腺瘤进行了研究。我们比较了同时患有同步癌的“高风险”患者和仅患有偶发性息肉的“低风险”患者的腺瘤。还包括二十三个化生性息肉和八个炎性息肉。我们的数据表明，大小和不典型增生并不总是密切相关，并且无论大小如何，同步性腺瘤似乎比偶发性息肉具有更高的恶性潜力。唾液酸的 O-酰化程度似乎是早期恶性变化的敏感指标：在所有 11 个具有高度非典型病灶（“局灶性癌”）的腺瘤中均观察到 O-酰化丧失，但仅在其余 4 个具有较低级别不典型增生的息肉中观察到 O-酰化丧失（P < 0.005）。相比之下，CEA 的染色强度是一个渐进的现象，并且随着恶性肿瘤的发生没有显示出统计学上显着的增加。炎性息肉表现出与正常粘膜相似的染色特征。然而，化生性息肉显示 CEA 表达增加，O-酰化减少，尺寸增加，这可能反映了生长和分化的障碍。最后，通过将这些染色谱与正常粘膜、癌旁“移行”粘膜和癌的染色谱进行比较，我们进一步说明了结肠粘膜在癌变过程中发生的变化的进展。
We have explored the merit of a simultaneous study of sialomucin content and carcinoembryonic antigen (CEA) expression in the identification of early malignancy in adenomas. One hundred and thirteen colorectal adenomas were investigated by histochemical and immunocytochemical techniques. We compared adenomas from ‘high risk’ patients having synchronous carcinoma and ‘low risk’ groups with incidental polyps only. Twenty‐three metaplastic and eight inflammatory polyps were also included. Our data suggest that size and dysplasia are not always closely related and that synchronous adenomas seem to carry a higher malignant potential than incidental polyps irrespective of size. The degree of O‐acylation of sialic acids appears to be a sensitive indicator of early malignant change: loss of O‐acylation was seen in all 11 adenomas with highly atypical foci (‘focal carcinoma’) but noted in only four of the remaining polyps with lower grade dysplasia (P< 0.005). By contrast the intensity of staining for CEA was a gradual phenomenon and showed no statistically significant increase with the onset of malignancy. Inflammatory polyps showed staining characteristics similar to normal mucosa. Metaplastic polyps, however, revealed increased expression of CEA and reduced O‐acylation with increased size which may reflect a disorder of growth and differentiation. Finally, by comparing these profiles of staining with those of normal mucosa,‘transitional’ mucosa adjacent to carcinoma and carcinoma, we further illustrate a progression of changes occurring in colonic mucosa in carcinogenesis.
大肠癌中的花生凝集素结合位点。
DOI：
--
发表时间：
1982
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Cooper,HS
通讯作者：
Cooper,HS
良性和恶性结直肠组织中癌胚抗原的免疫细胞化学定位。
影响因子：
3.5
作者：
O'Brien,MJ;Zamcheck,N;Burke,B;Kirkham,SE;Saravis,CA;Gottlieb,LS
通讯作者：
Gottlieb,LS