New trends in resuscitation.
New trends in resuscitation.
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DOI：
10.1067/j.cpsurg.2011.04.002
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发表时间：
2011-08
影响因子：
4.4
通讯作者：
Velmahos GC
中科院分区：
文献类型：
--
作者：
Alam HB;Velmahos GC
总体而言，伤害是美国第三大死亡原因，但它们不成比例地影响着我们社会中最年轻和最具生产力的部分。根据国家卫生统计中心的数据，伤害是44岁以下死亡和残疾的头号原因，1-34岁的美国人因伤害而死亡的人数超过所有其他疾病的总和。伤害的经济影响是惊人的-在2000年，需要医疗的5000万伤害最终将花费美国社会4060亿美元，其中包括802亿美元的医疗保健费用和3260亿美元的生产力损失2。对大型创伤中心的流行病学数据进行分析，揭示了一致的死亡模式3-7。多达一半的死亡发生在到达医院之前，由于大量失血或中枢神经系统（CNS）损伤。与严重的CNS损伤相比，出血导致的死亡可能是可以预防的，挽救生命的努力集中在早期控制出血和充分复苏。不幸的是，传统的复苏方法往往会加剧潜在的细胞损伤8。在被送往医院的患者中，大多数（70-80%）在最初的24-48小时内死亡，由于败血症和器官衰竭而死于晚期死亡的比例要小得多（< 10%）。由于创伤相关死亡主要发生在受伤后的前六个小时5，因此早期提供高质量的护理至关重要。尽管出血是一个常见的问题，但最佳复苏策略仍存在争议，关于液体类型、体积、速率、给药途径和复苏终点的争论激烈。随着我们对身体对出血和复苏反应的理解不断发展，这篇综述强调了复苏策略的最新进展。
Overall, injuries are the third leading cause of death in the United States, but they affect the younger and most productive segment of our society disproportionately. According to the National Center for Health Statistics, injuries are the number one cause of death and disability under age 44, and more Americans between the ages of 1–34 years are killed by injuries than by all other diseases combined1. The financial impact of injuries is staggering-50 million injuries that required medical treatment in 2000 will ultimately cost the US society $406 billion, including $80.2 billion in medical care costs and $326 billion in lost productivity2.Analysis of epidemiological data from large trauma centers reveals consistent patterns of death 3–7. Up to half of the deaths occur prior to arrival in a hospital as a result of massive blood loss or central nervous system (CNS) damage. Compared to severe CNS damage, death resulting from bleeding is potentially preventable, and life saving efforts focus on early control of bleeding and adequate resuscitation. Unfortunately, conventional resuscitation methods often exacerbate the underlying cellular injury8. Of the patients that are transported to the hospital, the majority (70–80%) dies within the first 24–48 hours, with a much smaller percentage (< 10%) succumbing to late death as a result of sepsis and organ failure. As hemorrhage-related deaths primarily occur in the first six hours after injury5, early delivery of high quality care is of critical importance. Despite hemorrhage being a common problem, the optimal resuscitative strategy remains controversial, with vigorous debates about the type of fluid, volume, rate, route of administration, and end points of resuscitation. This review highlights recent advances in resuscitation strategies as our understanding of the body’s response to hemorrhage and resuscitation has evolved.
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影响因子：
3.8
作者：
Alam, Hasan B.;Shuja, Fahad;Velmahos, George C.
通讯作者：
Velmahos, George C.
影响因子：
3.8
作者：
Alam, HB;Bowyer, MW;Rhee, P
通讯作者：
Rhee, P
DOI：
10.1080/10731190600974962
发表时间：
2007-01-01
期刊：
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
影响因子：
--
作者：
Bode, Arthur P.;Fischer, Thomas H.
通讯作者：
Fischer, Thomas H.
影响因子：
2.9
作者：
Bode, Arthur P.;Lust, Robert M.;Fischer, Thomas H.
通讯作者：
Fischer, Thomas H.
影响因子：
10.4
作者：
Blajchman, MA
通讯作者：
Blajchman, MA