Understanding the Impact of Hazardous and Harmful Use of Alcohol and/or Other Drugs on ARV Adherence and Disease Progression.

Understanding the Impact of Hazardous and Harmful Use of Alcohol and/or Other Drugs on ARV Adherence and Disease Progression.
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DOI:
10.1371/journal.pone.0125088
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发表时间:
2015
期刊:
影响因子:
3.7
通讯作者:
Parry C
Parry C
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Kader R;Govender R;Seedat S;Koch JR;Parry C

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本研究的目的是了解危险和有害使用酒精和/或其他药物对艾滋病毒患者抗逆转录病毒药物依从性和疾病进展的影响。采用横断面研究设计。共有1503名患者在南非开普敦的艾滋病诊所接受了问题药物使用筛查。607名患者的子样本(303名患者筛选阳性的问题物质使用和304名没有)参加了这项研究。危险或有害的酒精使用和有问题的药物使用预示着缺少和停止抗逆转录病毒药物治疗,这反过来又与CD4细胞计数减少、艾滋病毒疾病进展更快以及艾滋病毒/艾滋病感染者(艾滋病毒/艾滋病感染者)较差的健康结果有关。这项研究的结果强调需要采取综合方法来管理艾滋病患者的物质使用障碍。
The objective of this study was to understand the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression among HIV patients. A cross-sectional study design was used. A total of 1503 patients attending HIV clinics in Cape Town, South Africa were screened for problematic substance use. A sub-sample of 607 patients (303 patients who screened positive for problematic substance use and 304 who did not) participated in this study. Hazardous or harmful alcohol use and problematic drug use predicted missing and stopping ARVs which, in turn, was associated with a decrease in CD4 counts and more rapid HIV-disease progression and poorer health outcomes in people living with HIV/AIDS (PLWHA). The findings of this study underscore the need for an integrated approach to managing substance-use disorders in PLWHA.
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