Interplay of body mass index and metabolic syndrome: association with physiological age from midlife to late-life.
Interplay of body mass index and metabolic syndrome: association with physiological age from midlife to late-life.
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DOI：
10.1007/s11357-023-01032-9
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发表时间：
2024-04
期刊：
影响因子：
5.6
通讯作者：
Karlsson, Ida K.
中科院分区：
文献类型：
--
作者：
Ler, Peggy;Ploner, Alexander;Finkel, Deborah;Reynolds, Chandra A.;Zhan, Yiqiang;Jylhava, Juulia;Aslan, Anna K. Dahl;Karlsson, Ida K.
肥胖和代谢综合征（MetS）与衰老具有共同的病理生理特征。为了更好地理解它们之间的相互作用，我们研究了身体质量指数（BMI）和代谢当量是如何与生理年龄共同关联的，以及这种关联是否从中年到晚年发生了变化。我们使用了1825对瑞典双胞胎的纵向数据。生理年龄测量为虚弱指数（FI）和功能老化指数（FAI），并在线性混合效应模型中独立建模，调整了实足年龄、性别、教育程度和吸烟情况。我们评估了BMI和实足年龄与生理年龄之间的曲线关系，以及BMI、MetS和实足年龄之间的相互作用。我们发现BMI、MetS和实足年龄对FI有显著的三方交互作用（p-交互作用= 0.006），而对FAI没有影响。因此，我们将FI分析按年龄进行分层：< 65岁、65 - 85岁和≥85岁，并对不同年龄的FAI进行建模。除了≥85岁的FI外，BMI与FI和FAI呈u型相关，其中BMI在26-28 kg/m2左右与最低生理年龄相关。除了年龄< 65岁的FI外，MetS与较高的FI和FAI相关，并且修改了65 - 85岁的BMI-FI相关性（p-交互作用= 0.02），即MetS患者较高的BMI水平和FI之间的相关性更强。年龄对≥85岁的met - fi相关性有影响，且越高，met - fi相关性越强（p交互作用= 0.01）。低BMI、高BMI和代谢综合征与较高的生理年龄相关，有助于老年人的整体健康状况，并可能加速衰老。在线版本包含补充材料，可在10.1007/s11357-023-01032-9获得。
Obesity and metabolic syndrome (MetS) share common pathophysiological characteristics with aging. To better understand their interplay, we examined how body mass index (BMI) and MetS jointly associate with physiological age, and if the associations changed from midlife to late-life. We used longitudinal data from 1,825 Swedish twins. Physiological age was measured as frailty index (FI) and functional aging index (FAI) and modeled independently in linear mixed-effects models adjusted for chronological age, sex, education, and smoking. We assessed curvilinear associations of BMI and chronological age with physiological age, and interactions between BMI, MetS, and chronological age. We found a significant three-way interaction between BMI, MetS, and chronological age on FI (p-interaction = 0·006), not FAI. Consequently, we stratified FI analyses by age: < 65, 65–85, and ≥ 85 years, and modeled FAI across ages. Except for FI at ages ≥ 85, BMI had U-shaped associations with FI and FAI, where BMI around 26-28 kg/m2 was associated with the lowest physiological age. MetS was associated with higher FI and FAI, except for FI at ages < 65, and modified the BMI-FI association at ages 65–85 (p-interaction = 0·02), whereby the association between higher BMI levels and FI was stronger in individuals with MetS. Age modified the MetS-FI association in ages ≥ 85, such that it was stronger at higher ages (p-interaction = 0·01). Low BMI, high BMI, and metabolic syndrome were associated with higher physiological age, contributing to overall health status among older individuals and potentially accelerating aging. The online version contains supplementary material available at 10.1007/s11357-023-01032-9.
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影响因子：
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DOI：
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