Noncoding RNAs in cancer and cancer stem cells.
Noncoding RNAs in cancer and cancer stem cells.
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DOI：
10.5732/cjc.013.10170
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发表时间：
2013-11
影响因子：
--
通讯作者：
Cheng SY
中科院分区：
文献类型：
--
作者：
Huang T;Alvarez A;Hu B;Cheng SY
近年来，非编码RNA（ncRNA）在人类癌症中的重要性越来越明显。ncRNA的功能相关性对于microRNA（miRNA）和长非编码RNA（lncRNA）特别明显。miRNA是内源性表达的小RNA序列，其充当基因表达的转录后调节因子，并且已经对其在癌症中的作用进行了广泛研究，而lncRNA近年来正在成为癌症范例中的重要参与者。这些非编码基因通常在多种人类癌症中异常表达。然而，大多数ncRNA的生物学功能在很大程度上仍然未知。最近，已经开始积累描述ncRNA如何在癌症和癌症干细胞中失调的证据，癌症干细胞是具有自我更新和分化能力的癌细胞的子集。这些研究提供了深入了解ncRNA在肿瘤发生、进展和对治疗的抗性中发挥的功能作用，并且它们表明ncRNA是有吸引力的治疗靶点和潜在有用的诊断工具。
In recent years, it has become increasingly apparent that noncoding RNAs (ncRNA) are of crucial importance for human cancer. The functional relevance of ncRNAs is particularly evident for microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). miRNAs are endogenously expressed small RNA sequences that act as post-transcriptional regulators of gene expression and have been extensively studied for their roles in cancers, whereas lncRNAs are emerging as important players in the cancer paradigm in recent years. These noncoding genes are often aberrantly expressed in a variety of human cancers. However, the biological functions of most ncRNAs remain largely unknown. Recently, evidence has begun to accumulate describing how ncRNAs are dysregulated in cancer and cancer stem cells, a subset of cancer cells harboring self-renewal and differentiation capacities. These studies provide insight into the functional roles that ncRNAs play in tumor initiation, progression, and resistance to therapies, and they suggest ncRNAs as attractive therapeutic targets and potentially useful diagnostic tools.
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影响因子：
8
作者：
Braconi, C.;Kogure, T.;Valeri, N.;Huang, N.;Nuovo, G.;Costinean, S.;Negrini, M.;Miotto, E.;Croce, C. M.;Patel, T.
通讯作者：
Patel, T.
影响因子：
64.8
作者：
Chendrimada, TP;Gregory, RI;Shiekhattar, R
通讯作者：
Shiekhattar, R
DOI：
10.1126/science.1240925
发表时间：
2013-08-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Carpenter S;Aiello D;Atianand MK;Ricci EP;Gandhi P;Hall LL;Byron M;Monks B;Henry-Bezy M;Lawrence JB;O'Neill LA;Moore MJ;Caffrey DR;Fitzgerald KA
通讯作者：
Fitzgerald KA
DOI：
10.1073/pnas.1011098108
发表时间：
2011-01-11
影响因子：
11.1
作者：
Braconi, Chiara;Valeri, Nicola;Patel, Tushar
通讯作者：
Patel, Tushar
影响因子：
11.2
作者：
Corney, David C.;Flesken-Nikitin, Andrea;Nikitin, Alexander Yu.
通讯作者：
Nikitin, Alexander Yu.