Sirtuins and Renal Oxidative Stress.
Sirtuins and Renal Oxidative Stress.
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DOI：
10.3390/antiox10081198
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发表时间：
2021-07-27
期刊：
影响因子：
--
通讯作者：
Koya D
中科院分区：
文献类型：
--
作者：
Ogura Y;Kitada M;Koya D
肾功能衰竭是全球范围内日益严重的一个主要健康问题。为了改善临床结果，我们需要了解肾脏疾病的基本机制。衰老是肾脏疾病发生和发展的危险因素。随着年龄的增长，细胞会产生氧化剂和抗氧化剂的失衡，导致氧化应激和肾脏损伤的发生。卡路里限制(CR)被认为是一种饮食方法，可以延长寿命，减少氧化应激，并延缓与年龄相关的疾病的发生。Sirtuins是一种依赖于烟酰胺腺嘌呤二核苷酸(NAD)的组蛋白脱乙酰基酶，被认为是一种抗衰老分子，CR可诱导其表达。Sirtuin家族由七种酶(Sirt1-7)组成，参与与抗氧化剂和氧化应激相关的过程和功能，如DNA损伤修复和通过组蛋白和蛋白质去乙酰化的新陈代谢。事实上，sirtuins在抗氧化剂和氧化还原物质的调节中的作用已经被提出。因此，肾脏中sirtuins的激活可能代表了一种新的治疗策略，通过减少氧化应激来增强对肾脏疾病中多种致病因素的抵抗力。在这篇综述中，我们讨论了sirtuins与肾脏疾病中氧化应激的关系。
Renal failure is a major health problem that is increasing worldwide. To improve clinical outcomes, we need to understand the basic mechanisms of kidney disease. Aging is a risk factor for the development and progression of kidney disease. Cells develop an imbalance of oxidants and antioxidants as they age, resulting in oxidative stress and the development of kidney damage. Calorie restriction (CR) is recognized as a dietary approach that promotes longevity, reduces oxidative stress, and delays the onset of age-related diseases. Sirtuins, a type of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase, are considered to be anti-aging molecules, and CR induces their expression. The sirtuin family consists of seven enzymes (Sirt1–7) that are involved in processes and functions related to antioxidant and oxidative stress, such as DNA damage repair and metabolism through histone and protein deacetylation. In fact, a role for sirtuins in the regulation of antioxidants and redox substances has been suggested. Therefore, the activation of sirtuins in the kidney may represent a novel therapeutic strategy to enhancing resistance to many causative factors in kidney disease through the reduction of oxidative stress. In this review, we discuss the relationship between sirtuins and oxidative stress in renal disease.
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