Lipotoxic Proximal Tubular Injury: A Primary Event in Diabetic Kidney Disease.

Lipotoxic Proximal Tubular Injury: A Primary Event in Diabetic Kidney Disease.
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脂毒性近端肾小管损伤:糖尿病肾病的主要事件

DOI:
10.3389/fmed.2021.751529
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发表时间:
2021
影响因子:
3.9
通讯作者:
Guo J
Guo J
中科院分区:
医学3区
文献类型:
--
作者:
Wang H;Zhang S;Guo J

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糖尿病肾病的发病机制是一个复杂的过程,与脂毒性有很大关系。自从“肾毒性”的概念提出以来,许多研究证实,脂毒性在糖尿病肾病的发展过程中起着重要作用,并导致各种肾功能障碍。这篇综述将对糖尿病进展过程中主要发生在肾小管的脂毒性引起的肾脏损伤进行简要的总结,从而进一步导致肾小球功能障碍。最新研究表明,脂毒性介导的肾小管损伤可能是糖尿病肾病的一个重要事件。
The pathogenesis of diabetic nephropathy is a complex process that has a great relationship with lipotoxicity. Since the concept of “nephrotoxicity” was proposed, many studies have confirmed that lipotoxicity plays a significant role in the progression of diabetic nephropathy and causes various renal dysfunction. This review will make a brief summary of renal injury caused by lipotoxicity that occurs primarily and predominantly in renal tubules during diabetic progression, further leading to glomerular dysfunction. The latest research suggests that lipotoxicity-mediated tubular injury may be a major event in diabetic nephropathy.
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