Hippo signaling in oval cells and hepatocarcinogenesis.
Hippo signaling in oval cells and hepatocarcinogenesis.
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卵圆细胞中的河马信号传导和肝癌发生。
DOI：
10.1016/j.canlet.2010.12.008
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发表时间：
2011-03
期刊：
影响因子：
9.7
通讯作者：
Liu, LianXin
中科院分区：
文献类型：
--
作者：
Zheng, Tongsen;Wang, Jiabei;Jiang, Hongchi;Liu, LianXin
肝细胞癌（Hepatocellular carcinoma，HCC）是世界上最常见的恶性肿瘤之一，也是世界上第三大恶性肿瘤死亡原因。尽管不断开发新的治疗方法，但HCC患者的预后仍然非常差。在某种程度上，这可能与刺激HCC肿瘤发生的分子异常有关，也有助于降低对标准治疗的敏感性。越来越多的证据显示肝癌干细胞在肝癌发生中的重要性。虽然广泛研究，但对肝癌干细胞在肝肿瘤发生和进展中的重要信号通路知之甚少。Hippo信号通路在果蝇中被鉴定为细胞增殖和凋亡的重要调节因子。近年来，Hippo信号通路被认为参与了多种肿瘤的发生发展过程，并在多种肿瘤中发挥重要作用，尤其是在肝细胞癌中。有力的证据也证明了Hippo信号通路在卵圆细胞活化中的重要作用。如所建议的，Hippo信号传导具有Hippo在肝肿瘤抑制以及卵圆细胞向完全分化的肝细胞的转变中的双重调节。阐明Hippo信号通路在肝癌发生中的作用，有助于更好地理解肝癌的发生机制，为肝癌的合理药物治疗提供依据，并为其他肿瘤的治疗提供可能。在这里，我们提供了一个历史性的审查，这一有力的生长调节途径在肝癌和突出的问题，可能是未来的调查重点。
Hepatocellular carcinoma (HCC) is one of the most common malignancies and the third leading cause of cancer mortality world wide. Despite continuing development of new therapies, the prognosis for patients with HCC remains extremely poor. In part, this may relate to molecular abnormalities that stimulate HCC tumorigenesis and also contribute to reduced sensitivity to standard treatment. Increasing evidence has revealed the importance of liver cancer stem cells in hepatocarcinogenesis. Although widely investigated, the signaling pathways important for liver cancer stem cells in liver tumor initiation and progression are poorly understood. The Hippo signaling pathway was identified in Drosophila as an essential regulator of cell proliferation and apoptosis. Recently, Hippo pathway has been implicated in multiple events during development and it has also been proposed to play a vital role in several tumor types, especially in hepatocellular carcinoma. Strong evidences also proved the significant role of the Hippo signaling pathway in oval cell activation. As suggested, hippo signaling has a dual regulation of Hippo in liver tumor suppression as well as transition of oval cells to fully differentiated hepatocytes. Delineation of the malfunction of Hippo signaling pathway in HCC may lead to better understanding of hepatocarcinogenesis, rational medical therapy for HCC and possible therapy for other tumors. Here, we provide a historical review of this potent growth-regulatory pathway in HCC and highlight outstanding questions that will likely be the focus of future investigation.
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影响因子：
3.7
作者：
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