Association between Fok I vitamin D receptor gene (VDR) polymorphism and impulsivity in alcohol-dependent patients.
Association between Fok I vitamin D receptor gene (VDR) polymorphism and impulsivity in alcohol-dependent patients.
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DOI：
10.1007/s11033-014-3607-6
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发表时间：
2014-11
影响因子：
2.8
通讯作者：
Wojnar M
中科院分区：
文献类型：
--
作者：
Wrzosek M;Jakubczyk A;Wrzosek M;Kaleta B;Łukaszkiewicz J;Matsumoto H;Brower K;Nowicka G;Wojnar M
Vitamin D appears to have an important role in the modulation of the central nervous system. Vitamin D exerts its biological effects through its interaction with the vitamin D receptor (VDR). Located on chromosome 12 (12q13.1), the VDR gene has many different polymorphisms. Some of them are known to affect the VDR function, such as FokI (rs2228570, T/C) single nucleotide polymorphism. We aimed to explore a potential relationship between FokI VDR polymorphism and impulsiveness in alcohol-dependent (AD) patients. The study population consisted of 148 patients diagnosed with alcohol dependence (DSM-IV criteria) and 212 healthy controls. DNA was extracted from whole blood samples using the standard procedure. Genotypes were analyzed using a real-time PCR method. We found that FokI VDR gene polymorphism was associated with impulsivity [Barratt Impulsiveness Scale (BIS)-11 total score; P = 0.014], and with attentional impulsivity (BIS-11 subscale; P = 0.002) in the male AD patients. Our results suggest that CC FokI genotype of the VDR gene is associated with a higher level of impulsivity in these patients. This finding supports the hypothesis that impulsiveness, which significantly contributes to development of alcohol dependence, has a genetic background.
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DOI：
10.1111/j.1530-0277.2008.00648.x
发表时间：
2008-05-01
影响因子：
3.2
作者：
Saunders, Buddy;Farag, Noha;Lovallo, William R.
通讯作者：
Lovallo, William R.
DOI：
10.1111/j.1530-0277.2010.01217.x
发表时间：
2010-08
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Lejuez CW;Magidson JF;Mitchell SH;Sinha R;Stevens MC;de Wit H
通讯作者：
de Wit H
影响因子：
4.4
作者：
Huang, Jian;Xie, Zheng-Fu
通讯作者：
Xie, Zheng-Fu
影响因子：
17.7
作者：
Kalivas, PW;Volkow, ND
通讯作者：
Volkow, ND
影响因子：
2.8
作者：
Gonzalez-Reimers, Emilio;Alvisa-Negrin, Julio;Gonzalez-Diaz, Antonieta
通讯作者：
Gonzalez-Diaz, Antonieta