Immunogenetic variation shapes the gut microbiome in a natural vertebrate population.
Immunogenetic variation shapes the gut microbiome in a natural vertebrate population.
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DOI：
10.1186/s40168-022-01233-y
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发表时间：
2022-03-08
期刊：
影响因子：
15.5
通讯作者：
Richardson DS
中科院分区：
文献类型：
--
作者：
Davies CS;Worsley SF;Maher KH;Komdeur J;Burke T;Dugdale HL;Richardson DS
肠道微生物组（GM）可以影响宿主的许多生物过程，影响其健康和生存，但GM也会受到宿主性状的影响。在脊椎动物中，主要组织相容性复合体（MHC）基因在对抗病原体方面发挥着关键作用，并被认为塑造了宿主的GM。尽管如此--以及GM和MHC变异对个体适应性的重要性的记录--很少有研究调查野生环境中GM和MHC之间的联系。我们的特点是MHC I类（MHC-I），MHC II类（MHC-II）和GM的变化在个人内的自然种群的塞舌尔莺（Acrocephalus sechellensis）。我们确定的多样性和组成的GM变化与MHC特性，除了环境因素和其他主机特性。我们的研究结果表明，特定的MHC等位基因的存在下，但不是MHC的多样性，影响的多样性和组成的GM在这个人口。MHC-I等位基因，而不是MHC-II等位基因，对GM的影响最大。GM多样性与3个MHC-I等位基因（Ase-ua 3、Ase-ua 4、Ase-ua 5）和1个MHC-II等位基因（Ase-dab 4）的存在呈负相关，而GM组成的变化与4个不同MHC-I等位基因（Ase-ua 1、Ase-ua 7、Ase-ua 10、Ase-ua 11）的存在相关。GM多样性与TLR 3基因型之间无相关性，但与全基因组杂合度呈正相关，且随寄主年龄和田间时间而变化。这些结果表明，宿主免疫系统的组成部分在塑造野生动物的转基因方面发挥了作用。宿主基因型-特别是MHC-I和较小程度的MHC-II变异-可以调节GM，尽管这是直接发生的，还是通过对宿主健康的影响间接发生的，尚不清楚。重要的是，如果免疫基因可以通过调节微生物组来调节宿主健康，那么微生物组也可能影响免疫基因的选择。因此，宿主-微生物组协同进化可能在维持自然脊椎动物群体内的功能性免疫遗传变异方面发挥作用。视频摘要在线版本包含补充材料，可在10. 1186/s40168-022-01233-y。
The gut microbiome (GM) can influence many biological processes in the host, impacting its health and survival, but the GM can also be influenced by the host’s traits. In vertebrates, Major Histocompatibility Complex (MHC) genes play a pivotal role in combatting pathogens and are thought to shape the host’s GM. Despite this—and the documented importance of both GM and MHC variation to individual fitness—few studies have investigated the association between the GM and MHC in the wild. We characterised MHC class I (MHC-I), MHC class II (MHC-II) and GM variation in individuals within a natural population of the Seychelles warbler (Acrocephalus sechellensis). We determined how the diversity and composition of the GM varied with MHC characteristics, in addition to environmental factors and other host traits. Our results show that the presence of specific MHC alleles, but not MHC diversity, influences both the diversity and composition of the GM in this population. MHC-I alleles, rather than MHC-II alleles, had the greatest impact on the GM. GM diversity was negatively associated with the presence of three MHC-I alleles (Ase-ua3, Ase-ua4, Ase-ua5), and one MHC-II allele (Ase-dab4), while changes in GM composition were associated with the presence of four different MHC-I alleles (Ase-ua1, Ase-ua7, Ase-ua10, Ase-ua11). There were no associations between GM diversity and TLR3 genotype, but GM diversity was positively correlated with genome-wide heterozygosity and varied with host age and field period. These results suggest that components of the host’s immune system play a role in shaping the GM of wild animals. Host genotype—specifically MHC-I and to a lesser degree MHC-II variation—can modulate the GM, although whether this occurs directly, or indirectly through effects on host health, is unclear. Importantly, if immune genes can regulate host health through modulation of the microbiome, then it is plausible that the microbiome could also influence selection on immune genes. As such, host–microbiome coevolution may play a role in maintaining functional immunogenetic variation within natural vertebrate populations. Video abstract The online version contains supplementary material available at 10.1186/s40168-022-01233-y.
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
2.8
作者：
Cayrou, Caroline;Sambe, Bissoume;Drancourt, Michel
通讯作者：
Drancourt, Michel
影响因子：
4.9
作者：
Biedrzycka, Aleksandra;Bielanski, Wojciech;Radwan, Jacek
通讯作者：
Radwan, Jacek
影响因子：
2.6
作者：
Benskin, Clare McW. H.;Rhodes, Glenn;Pickup, Roger W.;Mainwaring, Mark C.;Wilson, Kenneth;Hartley, Ian R.
通讯作者：
Hartley, Ian R.
DOI：
10.1073/pnas.1000080107
发表时间：
2011-03-15
影响因子：
11.1
作者：
Caporaso, J. Gregory;Lauber, Christian L.;Knight, Rob
通讯作者：
Knight, Rob