Demystifying idiopathic interstitial pneumonia: time for more etiology-focused nomenclature in interstitial lung disease.
Demystifying idiopathic interstitial pneumonia: time for more etiology-focused nomenclature in interstitial lung disease.
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DOI：
10.1080/17476348.2022.2030710
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发表时间：
2022-03
影响因子：
3.9
通讯作者：
Galvin JR
中科院分区：
文献类型：
--
作者：
Todd NW;Atamas SP;Hines SE;Luzina IG;Shah NG;Britt EJ;Ghio AJ;Galvin JR
间质性肺病（ILD）的主要焦点集中在称为特发性间质性肺炎（IIP）的疾病上，其中包括特发性肺纤维化、特发性非特异性间质性肺炎、隐源性机化性肺炎和呼吸性细支气管炎-间质性肺病。我们回顾了9种疾病的放射学和组织学模式，这些疾病通过多学科方法分类为IIP，并描述了大量已发表的流行病学、转化和分子研究，这些研究表明它们与许多明确的环境暴露、职业暴露、肺部疾病、全身性疾病、药物毒性和遗传变异相关。在世纪，这些被称为IIP的疾病很少是特发性的，而是被充分描述的肺损伤的放射学和组织学模式，其与各种各样的病因相关。因此，特发性命名具有误导性和混淆性，也可能导致缺乏探究性，这表明确定ILD病因和启动以患者为中心的管理的彻底诊断过程的结束而不是开始。转向更注重病因学的命名将有利于所有人，包括希望改善生活质量和疾病结局的患者，促进其ILD知识的全科医学和肺科医生，以及正在推进ILD领域的专家ILD临床医生和研究人员。
A major focus of interstitial lung disease (ILD) has centered on disorders termed idiopathic interstitial pneumonias (IIPs) which include, among others, idiopathic pulmonary fibrosis, idiopathic nonspecific interstitial pneumonia, cryptogenic organizing pneumonia, and respiratory bronchiolitis-interstitial lung disease. We review the radiologic and histologic patterns for the nine disorders classified by multidisciplinary approach as IIP, and describe the remarkable amount of published epidemiologic, translational, and molecular studies demonstrating their associations with numerous yet definitive environmental exposures, occupational exposures, pulmonary diseases, systemic diseases, medication toxicities, and genetic variants. In the 21st century, these disorders termed IIPs are rarely idiopathic, but rather are well-described radiologic and histologic patterns of lung injury that are associated with a wide array of diverse etiologies. Accordingly, the idiopathic nomenclature is misleading and confusing, and may also promote a lack of inquisitiveness, suggesting the end rather than the beginning of a thorough diagnostic process to identify ILD etiology and initiate patient-centered management. A shift towards more etiology-focused nomenclature will be beneficial to all, including patients hoping for better life quality and disease outcome, general medicine and pulmonary physicians furthering their ILD knowledge, and expert ILD clinicians and researchers who are advancing the ILD field.
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影响因子：
9.6
作者：
Azadeh N;Limper AH;Carmona EM;Ryu JH
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Ryu JH
影响因子：
4.3
作者：
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影响因子：
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Matute-Bello, Gustavo
影响因子：
2.1
作者：
Adachi, Yoshitaka;Ozeki, Kazutaka;Kohno, Akio
通讯作者：
Kohno, Akio
DOI：
10.1183/13993003.02135-2019
发表时间：
2020-07
期刊：
The European respiratory journal
影响因子：
--
作者：
Bonifazi M;Sverzellati N;Negri E;Jacob J;Egashira R;Moser J;Piciucchi S;Mei F;De Lauretis A;Visca D;Goh N;Bonini M;Cirilli L;La Vecchia C;Chua F;Kouranos V;Margaritopoulos G;Kokosi M;Maher TM;Gasparini S;Gabrielli A;Wells AU;Renzoni EA
通讯作者：
Renzoni EA