The Role of Infection in Interstitial Lung Diseases: A Review.
The Role of Infection in Interstitial Lung Diseases: A Review.
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感染在间质性肺部疾病中的作用：综述。
DOI：
10.1016/j.chest.2017.03.033
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发表时间：
2017-10
期刊：
影响因子：
9.6
通讯作者：
Ryu JH
中科院分区：
文献类型：
--
作者：
Azadeh N;Limper AH;Carmona EM;Ryu JH
间质性肺疾病（ILD）包括一系列异质性肺实质疾病，这些疾病与一系列病理学、放射学和临床表现相关。有已知病因的ILD和特发性ILD，使治疗策略具有挑战性。根据ILD的类型，预后可能有所不同，但许多患者表现出渐进性进展，个体患者的临床病程不可预测，如特发性肺纤维化和“急性加重”（AE）现象。鉴于这些患者的预后往往较差，寻找呼吸恶化的可逆原因仍然至关重要。理论上，感染在ILD中发挥作用，在ILD的发病机制中以及作为AE的潜在触发因素。迄今为止的研究工作表明，与病毒病原体的相关性最高;然而，真菌和细菌生物体也有牵连。本文旨在总结目前对感染在ILD中的作用的认识。
Interstitial lung disease (ILD) comprises an array of heterogeneous parenchymal lung diseases that are associated with a spectrum of pathologic, radiologic, and clinical manifestations. There are ILDs with known causes and those that are idiopathic, making treatment strategies challenging. Prognosis can vary according to the type of ILD, but many exhibit gradual progression with an unpredictable clinical course in individual patients, as seen in idiopathic pulmonary fibrosis and the phenomenon of “acute exacerbation”(AE). Given the often poor prognosis of these patients, the search for a reversible cause of respiratory worsening remains paramount. Infections have been theorized to play a role in ILDs, both in the pathogenesis of ILD and as potential triggers of AE. Research efforts thus far have shown the highest association with viral pathogens; however, fungal and bacterial organisms have also been implicated. This review aims to summarize the current knowledge on the role of infections in the setting of ILD.
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