Association of circulating proprotein convertase subtilisin/kexin type 9 levels and the risk of incident type 2 diabetes in subjects with prediabetes: a population-based cohort study.
Association of circulating proprotein convertase subtilisin/kexin type 9 levels and the risk of incident type 2 diabetes in subjects with prediabetes: a population-based cohort study.
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循环前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型水平与糖尿病前期受试者发生 2 型糖尿病的风险之间的关系：一项基于人群的队列研究
DOI：
10.1186/s12933-020-01185-3
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发表时间：
2020-12-10
影响因子：
9.3
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Shi J;Zhang W;Niu Y;Lin N;Li X;Zhang H;Hu R;Ning G;Fan J;Qin L;Su Q;Yang Z
研究背景前蛋白转化酶枯草杆菌蛋白酶9（PCSK 9）通过靶向低密度脂蛋白受体调节胆固醇代谢。最近的研究表明，循环PCSK 9与葡萄糖稳态和胰岛素抵抗有关。本研究的目的是研究循环PCSK 9水平和2型糖尿病的发展与个体糖尿病前期。MethodsA人群为基础的前瞻性研究进行了4205例中国受试者与糖尿病前期（平均年龄56.1 ± 7.5岁）的关联。根据2010年美国糖尿病协会标准诊断为2型糖尿病。使用市售酶联免疫吸附试验（ELISA）测量循环PCSK 9水平。考克斯回归analysis.ResultsDuring a median follow-up period of 3.1 years，568例患者发生2型糖尿病。发生2型糖尿病的女性受试者的基线循环PCSK 9水平显著高于未发生2型糖尿病的女性受试者（p < 0.001）。在女性受试者中，PCSK 9最高四分位数组的2型糖尿病发病风险显著较高（危害比2.16; 95%置信区间1.16-4.04），在校正年龄、体重指数、腰围、C-反应蛋白、γ-谷氨酰转移酶、甘油三酯、低密度脂蛋白胆固醇、收缩压、和胰岛素抵抗评分的稳态模型评估。没有显着的关联PCSK 9和事件2型糖尿病男性subjects.ConclusionElevatedcirculatingPCSK9水平与2型糖尿病的发病率增加的女性受试者与糖尿病前期。
BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by targeting the low-density lipoprotein receptor. Recent studies have shown that circulating PCSK9 is associated with glucose homeostasis and insulin resistance. The aim of this study was to examine the association of circulating PCSK9 levels and risk for the development of type 2 diabetes in individuals with prediabetes.MethodsA population-based prospective study was conducted among 4205 Chinese subjects with prediabetes (average age 56.1 ± 7.5 years). Incident type 2 diabetes was diagnosed according to 2010 American Diabetes Association criteria. Circulating PCSK9 levels were measured using a commercially available enzyme-linked immunosorbent assay (ELISA). The association of circulating PCSK9 levels with the risk of incident type 2 diabetes was assessed by Cox regression analysis.ResultsDuring a median follow-up period of 3.1 years, 568 subjects developed type 2 diabetes. Baseline circulating PCSK9 levels were significantly higher in female subjects developing incident type 2 diabetes than in those not developing incident type 2 diabetes (p < 0.001). In female subjects, the risk of incident type 2 diabetes was significantly higher in the highest PCSK9 quartile group (hazard ratio 2.16; 95% confidence interval 1.16–4.04) than in the lowest quartile group after adjustments for age, body mass index, waist circumference, C-reactive protein, γ-glutamyltransferase, triglycerides, low-density lipoprotein cholesterol, systolic blood pressure, and homeostatic model assessment of insulin resistance score. No significant association was observed between PCSK9 and incident type 2 diabetes in male subjects.ConclusionElevated circulating PCSK9 levels are associated with an increased incidence of type 2 diabetes in female subjects with prediabetes.
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肥胖和 2 型糖尿病与年轻女性 PCSK9 水平升高有关。
影响因子：
3.4
作者：
Levenson AE;Shah AS;Khoury PR;Kimball TR;Urbina EM;de Ferranti SD;Maahs DM;Dolan LM;Wadwa RP;Biddinger SB
通讯作者：
Biddinger SB
影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
16.2
作者：
Fraser A;Harris R;Sattar N;Ebrahim S;Davey Smith G;Lawlor DA
通讯作者：
Lawlor DA
影响因子：
5.3
作者：
Bojanin, Dragana;Vekic, Jelena;Spasojevic-Kalimanovska, Vesna
通讯作者：
Spasojevic-Kalimanovska, Vesna
影响因子：
9.3
作者：
Ray, Kausik K.;Del Prato, Stefano;Leiter, Lawrence A.
通讯作者：
Leiter, Lawrence A.