A Preliminary Study on the Ability of the Trypsin-Like Peptidase Activity Assay Kit to Detect Periodontitis.
A Preliminary Study on the Ability of the Trypsin-Like Peptidase Activity Assay Kit to Detect Periodontitis.
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DOI：
10.3390/dj8030098
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发表时间：
2020-09-01
影响因子：
2.6
通讯作者：
Nishihara T
中科院分区：
文献类型：
--
作者：
Iwasaki M;Usui M;Ariyoshi W;Nakashima K;Nagai-Yoshioka Y;Inoue M;Nishihara T
本研究旨在探讨胰蛋白酶样肽酶活性测定试剂盒（TLP-AA-Kit），它测量的N-苯甲酰-dl-精氨酸肽酶（胰蛋白酶样肽酶）的活性，是否可以作为一个可靠的工具，牙周炎的检测，以人口为基础的监测。总共有105人接受了全口牙周检查，并提供舌拭子作为进一步分析的标本。TLP-AA-Kit的结果评分在1 - 5之间;评分越高表示胰蛋白酶浓度越高。受试者操作特征分析用于评估TLP-AA-Kit的预测有效性，其中疾病控制中心/美国牙周病学会提供的牙周炎病例定义作为参考。重度和中度牙周炎分别占研究人群的4.8%和16.2%。TLP-AA-Kit对重度牙周炎的诊断准确率较高，曲线下面积为0.93（95%置信区间= 0.88-0.99）。然而，TLP-AA-Kit对中/重度牙周炎的诊断准确性并不可靠。虽然需要进一步的研究来验证我们的结果，但本文提供的结果突出了TLP-AA-Kit作为牙周炎检测的有用工具的潜力，特别是在严重的情况下，用于基于人群的监测。
This study aimed to explore whether the Trypsin-Like Peptidase Activity Assay Kit (TLP-AA-Kit), which measures the activity of N-benzoyl-dl-arginine peptidase (trypsin-like peptidase), can be used as a reliable tool for periodontitis detection in population-based surveillance. In total, 105 individuals underwent a full-mouth periodontal examination and provided tongue swabs as specimens for further analyses. The results of the TLP-AA-Kit were scored between 1 and 5; higher scores indicated higher trypsin concentrations. Receiver operating characteristic analyses were used to evaluate the predictive validity of the TLP-AA-Kit, where the periodontitis case definition provided by the Centers for Disease Control/American Academy of Periodontology served as the reference. Severe and moderate periodontitis were identified in 4.8% and 16.2% of the study population, respectively. The TLP-AA-Kit showed high diagnostic accuracy for severe periodontitis, with an area under the curve of 0.93 (95% confidence interval = 0.88–0.99). However, the diagnostic accuracy of the TLP-AA-Kit for moderate/severe periodontitis was not reliable. While further studies are necessary to validate our results, the results provided herein highlight the potential of the TLP-AA-Kit as a useful tool for the detection of periodontitis, particularly in severe cases, for population-based surveillance.
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Stard 2015：用于报告诊断准确性研究的基本项目的更新列表。
DOI：
10.1136/bmj.h5527
发表时间：
2015-10-28
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
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影响因子：
18.6
作者：
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影响因子：
4.3
作者：
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通讯作者：
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影响因子：
8.3
作者：
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通讯作者：
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影响因子：
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作者：
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