Identification of glutathione modifications by cigarette smoke.
Identification of glutathione modifications by cigarette smoke.
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香烟烟雾对谷胱甘肽修饰的鉴定。
DOI：
10.1016/s0891-5849(02)01079-1
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发表时间：
2002
影响因子：
7.4
通讯作者：
A. van der Vliet
中科院分区：
文献类型：
--
作者：
S. Reddy;E. Finkelstein;P. Wong;A. Phung;C. Cross;A. van der Vliet
Although it has been recognized for decades that cigarette smoke (CS) is toxic to respiratory tract tissues, and that glutathione (GSH) and other thiols are able to ameliorate some of the adverse effects of CS, the precise interactions between thiols and critical CS components are only partially characterized. In the present study, we used HPLC and MALDI-MS approaches to more rigorously characterize the products of CS reactions with GSH, the major cellular thiol and an important antioxidant constituent in respiratory tract lining fluids, in an attempt to increase our understanding of mechanisms of CS respiratory tract toxicity. Exposure of solutions of GSH to gas phase CS resulted in its rapid depletion, and about 50% of this depletion could be accounted for by reaction with acrolein and crotonaldehyde, the two major α, β-unsaturated aldehydes in CS. Similar aldehyde adducts with GSH could also be detected in cells exposed to CS, although the relative yields were limited, presumably because of further reactions of these adducts and/or their excretion. Further characterization of in vivo thiol-aldehyde formation in respiratory tract cells can be expected to provide significant insights into the mechanisms of CS toxicity.
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影响因子：
2.9
作者：
REED, DJ;BABSON, JR;POTTER, DW
通讯作者：
POTTER, DW
线粒体谷胱甘肽和细胞蛋白巯基在谷胱甘肽耗尽的大鼠肝细胞甲醛毒性中的作用。
影响因子：
3.9
作者：
Ku,RH;Billings,RE
通讯作者：
Billings,RE
DOI：
10.1152/ajplung.2001.281.3.l732
发表时间：
2001-09-01
影响因子：
4.9
作者：
Finkelstein, EI;Nardini, M;Van der Vliet, A
通讯作者：
Van der Vliet, A
超氧化物歧化酶/H(2)O(2)介导的S-亚硝基谷胱甘肽释放一氧化氮的机制——谷氨酸的作用。
DOI：
10.1006/abbi.1999.1447
发表时间：
1999
期刊：
Archives of biochemistry and biophysics.
影响因子：
--
作者：
Singh,RJ;Hogg,N;Goss,SP;Antholine,WE;Kalyanaraman,B
通讯作者：
Kalyanaraman,B
DOI：
10.1006/taap.1996.0245
发表时间：
1996
期刊：
Toxicology and applied pharmacology.
影响因子：
--
作者：
Ramu,K;Perry,CS;Ahmed,T;Pakenham,G;Kehrer,JP
通讯作者：
Kehrer,JP