Increasing incidence of human melioidosis in Northeast Thailand.
Increasing incidence of human melioidosis in Northeast Thailand.
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DOI：
10.4269/ajtmh.2010.10-0038
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Peacock SJ
中科院分区：
文献类型：
--
作者：
Limmathurotsakul D;Wongratanacheewin S;Teerawattanasook N;Wongsuvan G;Chaisuksant S;Chetchotisakd P;Chaowagul W;Day NP;Peacock SJ
类鼻疽是一种严重的社区获得性传染病，由革兰氏阴性环境细菌类鼻疽伯克霍尔德氏菌引起。一项前瞻性队列研究确定了 1997 年至 2006 年间泰国东北部 Sappasithiprasong 医院收治的 2,243 名经培养证实患有类鼻疽病的患者。这些数据用于计算该省每年每 10 万人中有 12.7 例类鼻疽病的平均发病率。发病率从 2000 年的 8.0（95% 置信区间 [CI] = 7.2–10.0）逐渐增加到 2006 年的 21.3（95% CI = 19.2–23.6）（P < 0.001；趋势 χ2 检验）。男性、年龄≥45岁以及已知或未确诊的糖尿病是类鼻疽的独立危险因素。研究期间类鼻疽的平均死亡率为 42.6%。 2006年，类鼻疽的最低估计人口死亡率为每10万人8.63人（95% CI = 7.33-10.11），是泰国东北部传染病的第三大常见死因，仅次于人类免疫缺陷病毒（HIV）/获得性免疫缺陷综合症（AIDS）和结核病。
Melioidosis is a serious community-acquired infectious disease caused by the Gram-negative environmental bacterium Burkholderia pseudomallei. A prospective cohort study identified 2,243 patients admitted to Sappasithiprasong Hospital in northeast Thailand with culture-confirmed melioidosis between 1997 and 2006. These data were used to calculate an average incidence rate for the province of 12.7 cases of melioidosis per 100,000 people per year. Incidence increased incrementally from 8.0 (95% confidence interval [CI] = 7.2–10.0) in 2000 to 21.3 (95% CI = 19.2–23.6) in 2006 (P < 0.001; χ2 test for trend). Male sex, age ≥ 45 years, and either known or undiagnosed diabetes were independent risk factors for melioidosis. The average mortality rate from melioidosis over the study period was 42.6%. The minimum estimated population mortality rate from melioidosis in 2006 was 8.63 per 100,000 people (95% CI = 7.33–10.11), the third most common cause of death from infectious diseases in northeast Thailand after human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) and tuberculosis.
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影响因子：
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作者：
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