Detouring adrenergic stimulation to induce adipose thermogenesis.

Detouring adrenergic stimulation to induce adipose thermogenesis.
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DOI:
10.1038/s41574-021-00546-6
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发表时间:
2021-10
期刊:
Nature reviews. Endocrinology
影响因子:
--
通讯作者:
Kajimura S
Kajimura S
中科院分区:
其他
文献类型:
--
作者:
Auger C;Kajimura S

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利用脂肪细胞的产热、消耗能量的能力具有对抗代谢紊乱的潜力。虽然β3-肾上腺素能受体激动剂是最知名的产热激活剂,但它们具有相当大的心血管风险。一项新的研究表明,G蛋白偶联受体3能够独立于β3-肾上腺素能受体信号内在地驱动脂肪产热。
Harnessing the thermogenic, energy-expending capacity of adipocytes has the potential to combat metabolic disorders. Although β3-adrenergic receptor agonists are the best-known activators of thermogenesis, they carry considerable cardiovascular risks. A new study demonstrates the ability of G protein-coupled receptor 3 to intrinsically drive adipose thermogenesis independent of β3-adrenergic receptor signalling.
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